ArticleFrontiers in molecular neuroscience2011
Vascular growth in health and disease.
Article in Frontiers in molecular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial.Circulation · 2014Trial
- Mycn regulates vascular development through PI3K signaling pathway in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Computational Modeling Unveils the Impact of Tissue Growth and Vascular Remodeling on the Distribution of Interstitial Chemical Species.Annals of biomedical engineering · 2026Article
- Review
- Developmental and angiogenic safety profiles of novel pyridine-based chalcone.Frontiers in pharmacology · 2026Article
- De novo Dural Arteriovenous Fistula at the Drainer Site after Embolization of Brain Arteriovenous Malformation.Asian journal of neurosurgery · 2025Article
- Cerebral arterioles express the laminin subunits α4 and α5 in conjunction with α6β4 integrin, but strongly downregulate laminin α4 during hypoxia-induced arteriogenic remodeling.Microvascular research · 2024Article
- Pro-Angiogenetic Effects of Purified Extracts fromCurrent issues in molecular biology · 2022Article
- Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury.Regenerative therapy · 2022Review
- Coalescent angiogenesis-evidence for a novel concept of vascular network maturation.Angiogenesis · 2022Article
- Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion.Frontiers in cardiovascular medicine · 2022Article
- Simulating flow induced migration in vascular remodelling.PLoS computational biology · 2020Article
- Limb functional recovery is impaired in fibroblast growth factor-2 (FGF2) deficient mice despite chronic ischaemia-induced vascular growth.Growth factors (Chur, Switzerland) · 2020Article
- Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation.Frontiers in physiology · 2020Review
- Approaches to therapeutic angiogenesis for ischemic heart disease.Journal of molecular medicine (Berlin, Germany) · 2019Review
- Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function.Frontiers in physiology · 2019Article
- Arterial Hypertension and Unusual Ascending Aortic Dilatation in a Neonate With Acute Kidney Injury: Mechanistic Computer Modeling.Frontiers in physiology · 2019Article
- Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Influence of vascular endothelial growth factor inhibition on simple renal cysts in patients receiving bevacizumab-based chemotherapy.Korean journal of urology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular growth forms the first functional organ system during development, and continues into adult life, wherein it is often associated with disease states. Genetically determined vasculogenesis produces a primary vascular plexus during ontogenesis. Angiogenesis, occurring, e.g., in response to metabolic stress within hypoxic tissues, enhances tissue capillarization. Arteriogenesis denotes the adaptive outgrowth of pre-existent collateral arteries to bypass arterial stenoses in response to hemodynamic changes. It has been debated whether vasculogenesis occurs in the adult, and whether or not circulating progenitor cells structurally contribute to vessel regeneration. Secondly, the major determinants of vascular growth - genetic predisposition, metabolic factors (hypoxia), and hemodynamics - cannot be assigned in a mutually exclusive fashion to vasculogenesis, angiogenesis, and arteriogenesis, respectively; rather, mechanisms overlap. Lastly, all three mechanisms of vessel growth seem to contribute to physiological embryogenesis as well as adult adaptive vascularization as occurs in tumors or to circumvent arterial stenosis. Thus, much conceptual and terminological confusion has been created, while therapies targeting neovascularization have yielded promising results in the lab, but failed randomized studies when taken to the bedside. Therefore, this review article aims at providing an exact definition of the mechanisms of vascular growth and their contribution to embryonic development as well as adult adaptive revascularization. We have been looking for potential reasons for why clinical trials have failed, how vitally the application of appropriate methods of measuring and assessment influences study outcomes, and how relevant, e.g., results gained in models of vascular occlusive disease may be for antineoplastic strategies, advocating a reverse bedside-to-bench approach, which may hopefully yield successful approaches to therapeutically targeting vascular growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.