ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Regional variation in the mechanical role of knee meniscus glycosaminoglycans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- Hydration as a governing state variable in the mechanical and electrical response of decellularized extracellular matrix materials.Journal of materials science. Materials in medicine · 2026Article
- Integrating Mechanical Loading, Mechanotransduction, and Biological Responses in Musculoskeletal Tissues Across the Lifespan: Regulation Influenced by Cells, Extracellular Matrix, and Sex.Results and problems in cell differentiation · 2026Review
- Influence of in vitro test conditions on the Biomechanical properties of degenerated human lateral menisci.Journal of orthopaedic surgery and research · 2025Article
- Freeze drying and Lugol staining of human menisci reveal circumferential fibre volumes to guide meniscus implant design and virtual simulation.Scientific reports · 2025Article
- Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT.Heliyon · 2024Article
- Article
- High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quantitative imaging in medicine and surgery · 2024Article
- Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.Osteoarthritis and cartilage open · 2023Article
- Strain-Dependent Diffusivity of Small and Large Molecules in Meniscus.Journal of biomechanical engineering · 2022Article
- Effects of and Response to Mechanical Loading on the Knee.Sports medicine (Auckland, N.Z.) · 2022Review
- A Tale of Two Loads: Modulation of IL-1 Induced Inflammatory Responses of Meniscal Cells in Two Models of Dynamic Physiologic Loading.Frontiers in bioengineering and biotechnology · 2022Article
- Joint-adjacent Adipose Tissue by MRI is Associated With Prevalence and Progression of Knee Degenerative Changes: Data from the Osteoarthritis Initiative.Journal of magnetic resonance imaging : JMRI · 2021Article
- Viscoelastic and equilibrium shear properties of human meniscus: Relationships with tissue structure and composition.Journal of biomechanics · 2021Article
- Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments.Biomaterials · 2021Article
- Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins.Nano today · 2020Article
- Molecular and macromolecular diffusion in human meniscus: relationships with tissue structure and composition.Osteoarthritis and cartilage · 2020Article
- Degeneration Affects Three-Dimensional Strains in Human Menisci:Frontiers in bioengineering and biotechnology · 2020Article
- Compressive Properties and Hydraulic Permeability of Human Meniscus: Relationships With Tissue Structure and Composition.Frontiers in bioengineering and biotechnology · 2020Article
- Effects of tissue culture on the biomechanical properties of porcine meniscus explants.Clinical biomechanics (Bristol, Avon) · 2019Article
- Impacts of maturation on the micromechanics of the meniscus extracellular matrix.Journal of biomechanics · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
High compressive properties of cartilaginous tissues are commonly attributed to the sulfated glycosaminoglycan (GAG) fraction of the extracellular matrix (ECM), but this relationship has not been directly measured in the knee meniscus, which shows regional variation in GAG content. In this study, biopsies from each meniscus region (outer, middle, and inner) were either subjected to chondroitinase ABC (CABC) to remove all sulfated GAGs or not. Compressive testing revealed that GAG depletion in the inner and middle meniscus regions caused a significant decrease in modulus of relaxation (58% and 41% decreases, respectively, at 20% strain), and all regions exhibited a significant decrease in viscosity (outer: 29%; middle: 58%; inner: 62% decrease). Tensile properties following CABC treatment were unaffected for outer and middle meniscus specimens, but the inner meniscus displayed significant increases in Young's modulus (41% increase) and ultimate tensile stress (40% increase) following GAG depletion. These findings suggest that, in the outer meniscus, GAGs contribute to increasing tissue viscosity, whereas in the middle and inner meniscus, where GAGs are most abundant, these molecules also enhance the tissue's ability to withstand compressive loads. GAGs in the inner meniscus also contribute to reducing the circumferential tensile properties of the tissue, perhaps due to the pre-stress on the collagen network from increased hydration of the ECM. Understanding the mechanical role of GAGs in each region of the knee meniscus is important for understanding meniscus structure-function relationships and creating design criteria for functional meniscus tissue engineering efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.