ArticleJournal of medical microbiology2012
Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage.
Article in Journal of medical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- History and Evolution of the HypervirulentMicroorganisms · 2025Review
- In-depth characterization of accessory gene regulator loci and associated virulence factors inCurrent research in microbial sciences · 2025Article
- Article
- Review
- Ribotypes and New Virulent Strains Across Europe.Advances in experimental medicine and biology · 2024Review
- Comparative Genomics of Clostridioides difficile.Advances in experimental medicine and biology · 2024Article
- Biofilm Formation ofMicroorganisms · 2023Review
- Antibiotic resistance and genomic features ofPeerJ · 2022Article
- Comparison of clinical severity, genotype and toxin gene expression of binary toxin-producingAccess microbiology · 2022Article
- Effect of Restriction of Fluoroquinolone Antibiotics onAntibiotics (Basel, Switzerland) · 2021Article
- Extracellular DNA, cell surface proteins and c-di-GMP promote biofilm formation in Clostridioides difficile.Scientific reports · 2021Article
- Production ofFrontiers in cellular and infection microbiology · 2021Article
- The largely unnoticed spread ofInfection prevention in practice · 2020Review
- Induction of a Specific Humoral Immune Response by Nasal Delivery of Bcla2International journal of molecular sciences · 2020Article
- Antimicrobial Resistance inMicrobiology spectrum · 2020Review
- Single cell analysis of nutrient regulation of Clostridioides (Clostridium) difficile motility.Anaerobe · 2019Article
- Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage.EBioMedicine · 2019Article
- The predominance and clustering of Clostridioides (Clostridium) difficile PCR ribotype 001 isolates in three hospitals in Eastern Slovakia, 2017.Folia microbiologica · 2019Article
- Molecular typing and antimicrobial susceptibility testing to six antimicrobials of Clostridium difficile isolates from three Czech hospitals in Eastern Bohemia in 2011-2012.Folia microbiologica · 2017Article
- A genetic switch controls the production of flagella and toxins in Clostridium difficile.PLoS genetics · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
Clostridium difficile is the most common cause of antibiotic-associated diarrhoea worldwide. Over the past 10 years, the incidence and severity of disease have increased in North America and Europe due to the emergence of a hypervirulent clone designated PCR ribotype 027. In this study, we sought to identify phenotypic differences among a collection of 26 presumed PCR ribotype 027 strains from the US and the UK isolated between 1988 and 2008 and also re-evaluated the PCR ribotype. We demonstrated that some of the strains typed as BI by restriction endonuclease analysis, and presumed to be PCR ribotype 027, were in fact other PCR ribotypes such as 176, 198 and 244 due to slight variation in banding pattern compared to the 027 strains. The reassigned 176, 198 and 244 ribotype strains were isolated in the US between 2001 and 2004 and appeared to have evolved recently from the 027 lineage. In addition, the UK strains were more motile and more resistant to most of the antibiotics compared to the US counterparts. We conclude that there should be a heightened awareness of newly identified PCR ribotypes such as 176, 198 and 244, and that they may be as problematic as the notorious 027 strains.
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