ArticleThe Journal of pharmacology and experimental therapeutics2011
Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.
Article in The Journal of pharmacology and experimental therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- OLED catheters for inner-body phototherapy: A case of type 2 diabetes mellitus improved via duodenal photobiomodulation.Science advances · 2023Article
- Preclinical evaluation of tolvaptan and salsalate combination therapy in aFrontiers in molecular biosciences · 2023Article
- Alterations in Energy Metabolism, Mitochondrial Function and Redox Homeostasis in GK Diabetic Rat Tissues Treated with Aspirin.Life (Basel, Switzerland) · 2022Article
- Effect of Aspirin on Mitochondrial Dysfunction and Stress in the Pancreas and Heart of Goto-Kakizaki Diabetic Rats.Life (Basel, Switzerland) · 2021Article
- Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model.Journal of cellular and molecular medicine · 2019Article
- Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction.EBioMedicine · 2017Article
- A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats.Acta pharmacologica Sinica · 2017Article
- Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1.Diabetes · 2016 · on this mapArticle
- Modeling Disease Progression: Angiotensin II Indirectly Inhibits Nitric Oxide Production via ADMA Accumulation in Spontaneously Hypertensive Rats.Frontiers in physiology · 2016Article
- The effect of duodenojejunostomy and sleeve gastrectomy on type 2 diabetes mellitus and gastrin secretion in Goto-Kakizaki rats.Surgical endoscopy · 2015Article
- Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats.Gene regulation and systems biology · 2015Article
- Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Article
- Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Article
- A review of rodent models of type 2 diabetic skeletal fragility.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Review
- Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats.Journal of pharmaceutical sciences · 2013Article
- Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats.Biopharmaceutics & drug disposition · 2012Article
- Effects of high fat feeding on liver gene expression in diabetic goto-kakizaki rats.Gene regulation and systems biology · 2012Article
- Pharmacokinetic/pharmacodynamic modeling in inflammation.Critical reviews in biomedical engineering · 2012Review
- Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes.TheScientificWorldJournal · 2012Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Type 2 diabetes mellitus (T2DM) arises owing to insulin resistance and β-cell dysfunction. Chronic inflammation is widely identified as a cause of T2DM. The Goto-Kakizaki (GK) rat is a spontaneous rodent model for T2DM with chronic inflammation. The purpose of this study was to characterize diabetes progression in GK rats and evaluate the potential role of the anti-inflammatory agent salsalate. The GK rats were divided into control groups (n = 6) and salsalate treatment groups (n = 6), which were fed a salsalate-containing diet from 5 to 21 weeks of age. Blood glucose and salicylate concentrations were measured once a week. Glucose concentrations showed a biphasic increase in which the first phase started at approximately 5 weeks, resulting in an increase by 15 to 25 mg/dl and a second phase at 14 to 15 weeks with an upsurge of more than 100 mg/dl. A mechanism-based model was proposed to describe the natural diabetes progression and salsalate pharmacodynamics by using a population method in S-ADAPT. Two transduction cascades were applied to mimic the two T2DM components: insulin resistance and β-cell dysfunction. Salsalate suppressed both disease factors by a fraction of 0.622 on insulin resistance and 0.134 on β-cell dysfunction. The substantial alleviation of diabetes by salsalate supports the hypothesis that chronic inflammation is a pathogenic factor of diabetes in GK rats. In addition, body weight and food intake were measured and further modeled by a mechanism-based growth model. Modeling results suggest that salsalate reduces weight gain by enhancing metabolic rate and energy expenditure in both GK and Wister-Kyoto rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.