ArticleDevelopment (Cambridge, England)2011
Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025Review
- Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-αLN linker protein.JCI insight · 2022Article
- Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.PloS one · 2022Article
- Three-dimensional reconstructions of mouse circumvallate taste buds using serial blockface scanning electron microscopy: I. Cell types and the apical region of the taste bud.The Journal of comparative neurology · 2020Article
- The subsequent biological effects of simulated microgravity on endothelial cell growth in HUVECs.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Article
- Basement Membranes in Development and Disease.Current topics in developmental biology · 2018Review
- Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.Nature communications · 2017Article
- Laminin: loss-of-function studies.Cellular and molecular life sciences : CMLS · 2017Review
- Chimeric protein repair of laminin polymerization ameliorates muscular dystrophy phenotype.The Journal of clinical investigation · 2017Article
- Article
- Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.Molecular biology of the cell · 2015Article
- Hanging on for the ride: adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease.Developmental biology · 2015Review
- Signaling during Kidney Development.Cells · 2015Review
- Fibronectin regulation by vitamin C treatment in kidneys of nicotinic mice offspring.Iranian Red Crescent medical journal · 2014Article
- Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints.Cell cycle (Georgetown, Tex.) · 2014Article
- FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.Biology open · 2013Article
- Schwann cell myelination requires integration of laminin activities.Journal of cell science · 2012Article
- Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In order to understand the functions of laminins in the renal collecting system, the Lamc1 gene was inactivated in the developing mouse ureteric bud (UB). Embryos bearing null alleles exhibited laminin deficiency prior to mesenchymal tubular induction and either failed to develop a UB with involution of the mesenchyme, or developed small kidneys with decreased proliferation and branching, delayed renal vesicle formation and postnatal emergence of a water transport deficit. Embryonic day 12.5 kidneys revealed an almost complete absence of basement membrane proteins and reduced levels of α6 integrin and FGF2. mRNA levels for fibroblast growth factor 2 (FGF2) and mediators of the GDNF/RET and WNT11 signaling pathway were also decreased. Furthermore, collecting duct cells derived from laminin-deficient kidneys and grown in collagen gels were found to proliferate and branch slowly. The laminin-deficient cells exhibited decreased activation of growth factor- and integrin-dependent pathways, whereas heparin lyase-treated and β1 integrin-null cells exhibited more selective decreases. Collectively, these data support a requirement of γ1 laminins for assembly of the collecting duct system basement membrane, in which immobilized ligands act as solid-phase agonists to promote branching morphogenesis, growth and water transport functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.