ReviewSeminars in nephrology1990
Renal hypertrophy, growth factors, and nephropathy in diabetes mellitus.
Review in Seminars in nephrology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02911792 (Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration
Who cites it
6 citing papers in PubMed, 62 citations in OpenAlex.
- Long non-cording RNA XIST promoted cell proliferation and suppressed apoptosis by miR-423-5p/HMGA2 axis in diabetic nephropathy.Molecular and cellular biochemistry · 2021Article
- Characterization of Enlarged Kidneys and Their Potential for Inducing Diabetes in DEK Rats.Biology · 2021Article
- Apelin retards the progression of diabetic nephropathy.American journal of physiology. Renal physiology · 2013Article
- Nephron filtration rate and proximal tubular fluid reabsorption in the Akita mouse model of type I diabetes mellitus.F1000Research · 2013Article
- The role of high-fructose corn syrup in metabolic syndrome and hypertension.Current hypertension reports · 2010Review
- Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury.Journal of the American Society of Nephrology : JASN · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In early type 1 diabetes mellitus, hypertrophy of the kidney is a consistent finding. It is easily diagnosed using current noninvasive methods, especially ultrasonography. Renal functional changes occur in association with hypertrophy, most notably glomerular hyperfiltration. The structural counterpart of this functional change is an early increase in capillary filtration surface area. In most forms of nondiabetic renal hypertrophy, kidney size is closely linked to GFR, but in diabetes, hypertrophy persists after the clinical onset of overt kidney disease (microalbuminuria, hypertension, decreased GFR, etc). The fact that growth factors produced by the kidney can act in both an autocrine and paracrine fashion raises the possibility that the local effects of such substances may act as local mediators of kidney growth, but no such factor has been identified as the initiating or sustaining factor in diabetic hypertrophy. Failure of renal hypertrophy to reverse following strict glycemic control for a few months may turn out to be an important prognostic indicator of future progression of the renal disease, but this remains to be studied in a large group of patients.
Indexed as
Identifiers
2190281W2415874815What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.