ArticleTissue engineering. Part A2011
Renal tissue engineering with decellularized rhesus monkey kidneys: age-related differences.
Article in Tissue engineering. Part A, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current strategies on kidney regeneration using tissue engineering approaches: a systematic review.BMC nephrology · 2025Pooled it
- Decellularized Rat Lung Extracellular Matrix as an In Vitro Platform for Canine Yolk Sac-Derived Endothelial Precursor Cells for Pulmonary Endothelium Reconstruction Studies.Bioengineering (Basel, Switzerland) · 2026Article
- Biocompatibility of decellularized spinach leaves.npj biomedical innovations · 2025Article
- Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal.Bioactive materials · 2021Review
- The Renal Extracellular Matrix as a Supportive Scaffold for Kidney Tissue Engineering: Progress and Future Considerations.Advances in experimental medicine and biology · 2021Article
- Kidney tissue engineering using a well-preserved acellular rat kidney scaffold and mesenchymal stem cells.Veterinary research forum : an international quarterly journal · 2021Article
- The Challenge in Using Mesenchymal Stromal Cells for Recellularization of Decellularized Cartilage.Stem cell reviews and reports · 2017Review
- Advances in the Knowledge about Kidney Decellularization and Repopulation.Frontiers in bioengineering and biotechnology · 2017Review
- Update on Renal Replacement Therapy: Implantable Artificial Devices and Bioengineered Organs.Tissue engineering. Part B, Reviews · 2016Review
- Mimicking the Kidney: A Key Role in Organ-on-Chip Development.Micromachines · 2016Review
- Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice.PloS one · 2016Article
- Inhibition of Pseudomonas aeruginosa biofilm formation by 2,2'-bipyridyl, lipoic, kojic and picolinic acids.Iranian journal of basic medical sciences · 2015Article
- Decellularized kidney in the presence of chondroitin sulfate as a natural 3D scaffold for stem cells.Iranian journal of basic medical sciences · 2015Article
- Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering.PloS one · 2015Article
- A review of cellularization strategies for tissue engineering of whole organs.Frontiers in bioengineering and biotechnology · 2015Review
- Article
- Bioengineering kidneys for transplantation.Seminars in nephrology · 2014Review
- Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization.Acta biomaterialia · 2014Review
- Tissue-engineered kidney disease models.Advanced drug delivery reviews · 2014Review
- Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies.Organogenesis · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
New therapies for severely damaged kidneys are needed due to limited regenerative capacity and organ donor shortages. The goal of this study was to repopulate decellularized kidney sections in vitro and to determine the impact of donor age on recellularization. This was addressed by generating decellularized kidney scaffolds from fetal, juvenile, and adult rhesus monkey kidney sections using a procedure that removes cellular components while preserving the structural and functional properties of the native extracellular matrix (ECM). Kidney scaffolds were recellularized using explants from different age groups (fetal, juvenile, adult) and fetal renal cell fractions. Results showed vimentin+ cytokeratin+ calbindin+ cell infiltration and organization around the scaffold ECM. The extent of cellular repopulation was greatest with scaffolds from the youngest donors, and with seeding of mixed fetal renal aggregates that formed tubular structures within the kidney scaffolds. These findings suggest that decellularized kidney sections from different age groups can be effectively repopulated with donor cells and the age of the donor is a critical factor in repopulation efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.