Evidence map›Paper›PMID 21902590›Full record

ArticleAIDS research and human retroviruses2012

Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.

Somi Sankaran Prakash, Rajesh Kalra, Rakesh Lodha, Sushil K Kabra, Kalpana Luthra

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Somi Sankaran PrakashDepartment of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Rajesh Kalra
Rakesh Lodha
Sushil K Kabra
Kalpana Luthra

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.

Indexed as

ChildChild, PreschoolFemaleGenetic VariationHIV Envelope Protein gp120HIV SeropositivityHumansIndiaInfantMaleMolecular Sequence DataPhylogenyReceptors, CCR5Receptors, CXCR4HIV Envelope Protein gp120Receptors, CCR5Receptors, CXCR4

Identifiers

PMID21902590
PMCPMC3332366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.