Evidence map›Paper›PMID 21902583›Full record

ArticleAIDS research and human retroviruses2012

C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.

Robert Y Choi, Keith R Fowke, Jennifer Juno, Barbara Lohman-Payne, Julius O Oyugi, Elizabeth R Brown, Rose Bosire, Grace John-Stewart, Carey Farquhar

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Robert Y ChoiDepartment of Medicine, University of Washington, Seattle, Washington 98104, USA. ryc@u.washington.edu
Keith R Fowke
Jennifer Juno
Barbara Lohman-Payne
Julius O Oyugi
Elizabeth R Brown
Rose Bosire
Grace John-Stewart
Carey Farquhar
University of Washington · USUniversity of Manitoba · CAKenya Medical Research Institute · KEUniversity of Nairobi · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
INTERNATIONAL TRAINING GRANT IN EPIDEMIOLOGYD43TW000007 · FIC · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 1988 to 2012
$16.3M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
HIV-1 and Protective Immunity against Common Childhood PathogensK24AI087399 · NIAID · UNIVERSITY OF WASHINGTON · PI FARQUHAR, CAREY · 2010 to 2014
$647k
The role of HIV-1 neutralizing mucosal IgA and lgG and genital shedding of HIV-1K01TW008406 · FIC · UNIVERSITY OF WASHINGTON · PI CHOI, ROBERT · 2010 to 2012
$366k
CIHR HOP-75348CIHR MDP-86721CIHR MOP-81377FIC NIH HHS D43 TW000007FIC NIH HHS K01 TW008406FIC NIH HHS R24 TW007988NIAID NIH HHS K24 AI87399NIAID NIH HHS P30 AI027757NICHD NIH HHS HD-23412NICHD NIH HHS K24 HD054314NICHD NIH HHS K24 HD54314NICHD NIH HHS R01 HD023412
6 · The paper itself

Abstract

The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.

Indexed as

Polymorphism, Single NucleotideAdultArginineCD4 AntigensCD4 Lymphocyte CountCohort StudiesDisease ProgressionFemaleGenotypeHIV-1HIV InfectionsHumansInfant, NewbornKenyaPostpartum PeriodPregnancyArginineCD4 AntigensTryptophanZidovudine

Identifiers

PMID21902583
PMCPMC3358105
OpenAlexW2159698320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.