ArticlePhysical review letters2011
Dynamics of DNA replication in yeast.
Article in Physical review letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Regulation of replication timing in Saccharomyces cerevisiae.PLoS computational biology · 2025Article
- Modeling the Dynamics of Eukaryotic DNA Synthesis in Remembrance of Tunde Ogunnaike.Industrial & engineering chemistry research · 2023Article
- Article
- Stochasticity of replication forks' speeds plays a key role in the dynamics of DNA replication.PLoS computational biology · 2019Article
- Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data.Nucleic acids research · 2019Article
- On the Interplay of the DNA Replication Program and the Intra-S Phase Checkpoint Pathway.Genes · 2019Review
- Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics.Nucleic acids research · 2017Article
- Model-based analysis of DNA replication profiles: predicting replication fork velocity and initiation rate by profiling free-cycling cells.Genome research · 2017Article
- Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations.Scientific reports · 2016Article
- Replication timing is regulated by the number of MCMs loaded at origins.Genome research · 2015Article
- The dynamics of genome replication using deep sequencing.Nucleic acids research · 2014Article
- Article
- High-resolution replication profiles define the stochastic nature of genome replication initiation and termination.Cell reports · 2013Article
- DNA replication timing.Cold Spring Harbor perspectives in biology · 2013Review
- Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.Nature protocols · 2013Article
- Mathematical modeling of genome replication.Physical review. E, Statistical, nonlinear, and soft matter physics · 2012Article
- Replication timing and its emergence from stochastic processes.Trends in genetics : TIG · 2012Review
- Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.PLoS biology · 2012Article
- A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations.BMC systems biology · 2012Article
- Do replication forks control late origin firing in Saccharomyces cerevisiae?Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, that mean replication time curves cannot be used to directly determine origin parameters. We demonstrate that the stochastic nature of replication dynamics leaves a clear signature in experimentally measured population average data, and we show that the width of the activation time probability distribution can be inferred from this data. Our results compare favorably with experimental measurements in Saccharomyces cerevisae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.