ArticleJournal of the American Chemical Society2011
Computational design of a collagen A:B:C-type heterotrimer.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- De Novo Design of Specific Heterotrimeric Collagen-Like Peptides via Genetic Algorithm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Stability of collagen heterotrimer with same charge pattern and different charged residue identities.Biophysical journal · 2023Article
- Disrupting Effects of Osteogenesis Imperfecta Mutations Could Be Predicted by Local Hydrogen Bonding Energy.Biomolecules · 2022Article
- Article
- Composition-dependent energetic contribution of complex salt bridges to collagen stability.Biophysical journal · 2021Article
- Predicting the stability of homotrimeric and heterotrimeric collagen helices.Nature chemistry · 2021Article
- Combining simulations and experiments for the molecular engineering of multifunctional collagen mimetic peptide-based materials.Soft matter · 2021Article
- Collagen Mimetic Peptides.Bioengineering (Basel, Switzerland) · 2021Review
- How electrostatic networks modulate specificity and stability of collagen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design.Bioinformatics (Oxford, England) · 2017Article
- Searching for the Pareto frontier in multi-objective protein design.Biophysical reviews · 2017Review
- Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Journal of the American Chemical Society · 2016Article
- Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Journal of the American Chemical Society · 2016Article
- NMR studies demonstrate a unique AAB composition and chain register for a heterotrimeric type IV collagen model peptide containing a natural interruption site.The Journal of biological chemistry · 2015Article
- Metal Stabilization of Collagen and de Novo Designed Mimetic Peptides.Biochemistry · 2015Article
- Empirical estimation of local dielectric constants: Toward atomistic design of collagen mimetic peptides.Biopolymers · 2015Article
- Design of net-charged abc-type collagen heterotrimers.Journal of structural biology · 2014Article
- Control of Collagen Stability and Heterotrimer Specificity through Repulsive Electrostatic Interactions.Biomolecules · 2013Article
- Circular permutation directs orthogonal assembly in complex collagen peptide mixtures.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have successfully designed an A:B:C collagen peptide heterotrimer using an automated computational approach. The algorithm maximizes the energy gap between the target and competing misfolded states while enforcing a minimum target stability. Circular dichroism (CD) measurements confirm that all three peptides are required to form a stable, structured triple helix. This study highlights the power of automated computational design, providing model systems to probe the biophysics of collagen assembly and developing general methods for the design of fibrous proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.