ArticleAnatomical record (Hoboken, N.J. : 2007)2011
Dystrophic serotonin axons in postmortem brains from young autism patients.
Article in Anatomical record (Hoboken, N.J. : 2007), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Common and distinct changes of regional resting-state brain activity between high- and low-functioning autism spectrum disorder.BMC psychiatry · 2026Article
- Review: Dopamine, Serotonin, and the Translational Neuroscience of Aggression in Autism Spectrum Disorder.JAACAP open · 2025Review
- Phytochemical, In Silico, In Vitro, and In Vivo Research on Piptadeniastrum africanum (Fabaceae) Unveiling Anti-Stereotypic, Anxiolytic, and Analgesic Effects in a Sodium Valproate-Induced Autistic Disorders Model.Brain and behavior · 2025Article
- Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024Review
- Plant-mediated green synthesis of gold nanoparticles using an aqueous extract ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder.Current neuropharmacology · 2024Review
- Juvenile handling rescues autism-related effects of prenatal exposure to valproic acid.Scientific reports · 2022Article
- Therapeutic Effects of a Novel Form of Biotin on Propionic Acid-Induced Autistic Features in Rats.Nutrients · 2022Article
- Pathophysiological Studies of Monoaminergic Neurotransmission Systems in Valproic Acid-Induced Model of Autism Spectrum Disorder.Biomedicines · 2022Review
- Autism spectrum disorders pathogenesis: Toward a comprehensive model based on neuroanatomic and neurodevelopment considerations.Frontiers in neuroscience · 2022Article
- Functional and Neuropathological Evidence for a Role of the Brainstem in Autism.Frontiers in integrative neuroscience · 2021Article
- Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.Molecular autism · 2020Article
- Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity.Frontiers in neuroscience · 2019Review
- Evidence for Brainstem Contributions to Autism Spectrum Disorders.Frontiers in integrative neuroscience · 2018Review
- Autism spectrum disorder: neuropathology and animal models.Acta neuropathologica · 2017Review
- Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum.Journal of autism and developmental disorders · 2016Article
- Olfactory processing in adults with autism spectrum disorders.Molecular autism · 2016Article
- Neurobiological abnormalities in the first few years of life in individuals later diagnosed with autism spectrum disorder: a review of recent data.Behavioural neurology · 2014Review
- Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats.Frontiers in cellular neuroscience · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Autism causes neuropathological changes in varied anatomical loci. A coherent neural mechanism to explain the spectrum of autistic symptomatology has not been proposed because most anatomical researchers focus on point-to-point functional neural systems (e.g., auditory and social networks) rather than considering global chemical neural systems. Serotonergic neurons have a global innervation pattern. Disorders Research Program, AS073234, Program Project (JW). Their cell bodies are found in the midbrain but they project their axons throughout the neural axis beginning in the fetal brain. This global system is implicated in autism by animal models and by biochemical, imaging, pharmacological, and genetics studies. However, no anatomical studies of the 5-HT innervation of autistic donors have been reported. Our review presents immunocytochemical evidence of an increase in 5-HT axons in postmortem brain tissue from autism donors aged 2.8-29 years relative to controls. This increase is observed in the principle ascending fiber bundles of the medial and lateral forebrain bundles, and in the innervation density of the amygdala and the piriform, superior temporal, and parahippocampal cortices. In autistic donors 8 years of age and up, several types of dystrophic 5-HT axons were seen in the termination fields. One class of these dystrophic axons, the thick heavily stained axons, was not seen in the brains of patients with neurodegenerative diseases. These findings provide morphological evidence for the involvement of serotonin neurons in the early etiology of autism, and suggest new therapies may be effective to blunt serotonin's trophic actions during early brain development in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.