Evidence map›Paper›PMID 21901775›Full record

ReviewHead & neck2011

Control of the pharyngeal musculature during wakefulness and sleep: implications in normal controls and sleep apnea.

Bradley A Edwards, David P White

Open access · greenAbstract readReview
In one paragraph

Review in Head & neck, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Inspiratory muscle training as adjuvant therapy in obstructive sleep apnea: a randomized controlled trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Trial
  3. Epithelial NaJournal of sleep research · 2026
    Article
  4. KalinixSleep & breathing = Schlaf & Atmung · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Obstructive sleep apnea.Handbook of clinical neurology · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Bradley A EdwardsDivision of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. baedwards@partners.org
David P White
Harvard University · USMass General Brigham · US

Funding

SLEEP, AIRWAY PATENCY, AND THE PHARYNGEAL MUSCULATURER01HL048531 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WHITE, DAVID P. · 1992 to 2009
$3.8M
Integrative Neural Systems Underlying Vital Aerodigestive Tract FunctionsR13DC009556 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI ROBBINS, JOANNE · 2009 to 2010
$38k
NHLBI NIH HHS 5R01HL048531-16NHLBI NIH HHS R01 HL048531NIDCD NIH HHS 1R13DC009556-01A1S1
6 · The paper itself

Abstract

Respiration involves the complex coordination of several pump and upper airway/pharyngeal muscles. From a respiratory perspective, the major function of the pharyngeal muscles is to keep the airway patent allowing for airflow in and out of the lung with minimal work by the respiratory pump muscles. The activity of each of the pharyngeal muscles varies depending on its function, but many reduce their activity during sleep. In healthy individuals, these muscles can respond to respiratory stimuli during sleep to prevent airway collapse. However, in individuals with an anatomically small airway, the muscles cannot always compensate for the increased mechanical load. Thus a vulnerable situation in which the airway is prone to collapse may occur with the development of obstructive sleep apnea. This article describes the current understanding regarding the control of the pharyngeal musculature during wakefulness and sleep, as well as the implications for obstructive sleep apnea.

Indexed as

Respiratory MechanicsSleepWakefulnessAirway ObstructionHumansPharyngeal MusclesRespiratory MusclesSleep Apnea, Obstructive

Identifiers

PMID21901775
PMCPMC3179569
OpenAlexW2043350376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.