ArticleAdvances in experimental medicine and biology2011
Human fibroblasts for large-scale "omics" investigations of ATM gene function.
Article in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Global metabolomic responses in urine from atm deficient mice in response to LDEnvironmental and molecular mutagenesis · 2018Article
- A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant.PloS one · 2018Article
- Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas.Scientific reports · 2016Article
- Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.Oncotarget · 2015Article
- Functional proteomics analysis to study ATM dependent signaling in response to ionizing radiation.Radiation research · 2013Article
- The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.Nature reviews. Molecular cell biology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
ATM (gene mutated in ataxia-telangiectasia) is a critical central component of the pleiotropic responses of cells to ionizing radiation-induced stress. To gain insight into molecular mechanisms and to enhance our understanding of ATM functions, we have advanced a human model cell system, derived from genetically defined immortal fibroblasts, and we have applied high-throughput genomic, proteomic and metabolomic technologies for a systems level analysis. The cellular characterizations reported here provide the background for application of a systems analysis to integrate transcription, post-translational modifications and metabolic activity induced by exposure of cells to ionizing radiation. We present here a summary of the derivation and characterization of cells comprising this model cell system and review applications of this model to systems analysis of ATM functions.
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Registered trials
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