Evidence map›Paper›PMID 21901431›Full record

ReviewCurrent atherosclerosis reports2011

Effects of diet on high-density lipoprotein cholesterol.

Patty W Siri-Tarino

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Social epidemiology of cardiometabolic risk factors in early adolescents.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  8. The Lipidomic Profile Discriminates Between MASLD and MetALD.Alimentary pharmacology & therapeutics · 2025
    Article
  9. Review
  10. Article
  11. Fatty acid profile and effect of Plukenetia volubilis L. (sacha inchi) oil on lipid metabolism in rats fed a high-fat diet.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Interaction betweenNutrients · 2023
    Article
  18. Article
  19. The Effect ofFoods (Basel, Switzerland) · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Patty W Siri-TarinoAtherosclerosis Research, Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA. psiri@chori.org
OASIS Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple dietary factors have been shown to increase high-density lipoprotein cholesterol (HDL-C) concentrations, and HDL-C has been inversely associated with coronary heart disease (CHD) risk. Replacement of dietary carbohydrate with polyunsaturated, monounsaturated and saturated fat has been associated with progressively greater increases in HDL-C (7-12%) in addition to other lipid changes. Added sugars, but not high glycemic carbohydrates, have been associated with decreased HDL-C. Alcohol consumption has been associated with increased HDL-C (9.2%) independent of changes in other measured lipids. Modest effects on HDL-C (~4-5%) among other lipid and non-lipid CHD risk factors have also been observed with weight loss by dieting, omega-3 fatty acids, and a Mediterranean diet pattern. The CHD benefit of increasing HDL-C is unclear given the inconsistent evidence from HDL-raising pharmacologic trials. Furthermore, pleiotropic effects of diet preclude attribution of CHD benefit specifically to HDL-C. Investigation into functional or other properties of HDL may lend further insight.

Indexed as

DietAlcohol DrinkingCholesterol, HDLCoronary DiseaseDietary FatsDiet, Carbohydrate-RestrictedDiet, MediterraneanDiet, ReducingFatty Acids, Omega-3HumansMetabolic SyndromeRisk FactorsWeight LossCholesterol, HDLDietary FatsFatty Acids, Omega-3

Identifiers

PMID21901431
OpenAlexW1965715040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.