SynthesisBrain imaging and behavior2011
Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder.
Synthesis in Brain imaging and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Meta-analytical transdiagnostic neural correlates in common pediatric psychiatric disorders.Scientific reports · 2022Pooled it
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.Molecular psychiatry · 2017Pooled it
- Meta-analysis of Functional Neuroimaging of Major Depressive Disorder in Youth.JAMA psychiatry · 2015Pooled it
- Executive function and attention in children and adolescents with depressive disorders: a systematic review.European child & adolescent psychiatry · 2015Pooled it
- Functional brain imaging studies of youth depression: a systematic review.NeuroImage. Clinical · 2014Pooled it
- Brain and behavioral correlates of insulin resistance in youth with depression and obesity.Hormones and behavior · 2019Trial
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review.Frontiers in psychiatry · 2026Review
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- Neuroimaging and Emotional Development in the Pediatric Population: Understanding the Link Between the Brain, Emotions, and Behavior.Pediatric reports · 2025Review
- Brain connectivity and transcriptional changes induced by rTMS in first-episode major depressive disorder.Translational psychiatry · 2025Article
- The Use of MRI and TMS in Treatment-Resistant Depression: Advances in Pediatric Applications.Brain sciences · 2025Review
- What Do We Know About Depression Among Youth and How Can We Make Progress Toward Improved Understanding and Reducing Distress? A New Hope.Clinical child and family psychology review · 2023Review
- Systematic Review: White Matter Microstructural Organization in Adolescents With Depression.JAACAP open · 2023Article
- Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.Molecular brain · 2023Article
- A Narrative Review about Prosocial and Antisocial Behavior in Childhood: The Relationship with Shame and Moral Development.Children (Basel, Switzerland) · 2022Review
- Mindfulness-Enhanced Computerized Cognitive Training for Depression: An Integrative Review and Proposed Model Targeting the Cognitive Control and Default-Mode Networks.Brain sciences · 2022Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Child and adolescent psychiatric neuroimaging research typically lags behind similar advances in adult disorders. While the pediatric depression imaging literature is less developed, a recent surge in interest has created the need for a synthetic review of this work. Major findings from pediatric volumetric and functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and resting state functional connectivity studies converge to implicate a corticolimbic network of key areas that work together to mediate the task of emotion regulation. Imaging the brain of children and adolescents with unipolar depression began with volumetric studies of isolated brain regions that served to identify key prefrontal, cingulate and limbic nodes of depression-related circuitry elucidated from more recent advances in DTI and functional connectivity imaging. Systematic review of these studies preliminarily suggests developmental differences between findings in youth and adults, including prodromal neurobiological features, along with some continuity across development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.