ArticleJournal of clinical immunology2011
Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis.
Article in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TNature medicine · 2023Article
- Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity.The Journal of clinical investigation · 2023Article
- Peptidomics analysis of plasma in patients with ankylosing spondylitis.Frontiers in immunology · 2023Article
- Article
- Microbial modulation of intestinal T helper cell responses and implications for disease and therapy.Mucosal immunology · 2020Review
- Circulating and Tissue-Resident CD4Gastroenterology · 2017Article
- Infectious Agents and Inflammation: The Role of Microbiota in Autoimmune Arthritis.Frontiers in microbiology · 2017Review
- Microbiota and chronic inflammatory arthritis: an interwoven link.Journal of translational medicine · 2016Review
- Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation.Immunology and cell biology · 2016Article
- Review
- Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.Frontiers in immunology · 2014Review
- Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo clarify the impact of T cell responses towards enteric antigens for chronic intestinal inflammation, we determined T helper 1 reactivity towards conserved Escherichia coli proteins in patients with Crohn's disease (CD) and healthy individuals and patients with ankylosing spondylitis (AS), who also often show microscopic inflammatory lesions within the gut or even develop overt inflammatory bowel disease.
methodsWe determined the frequency of IFNγ+CD40L+ cells/CD4+ T cells after stimulation of whole blood with pools of E. coli proteins.
resultsThe E. coli-specific Th1 response was significantly reduced in CD patients and to a lower extent also in AS patients.
conclusionsE. coli is a target for polyclonal Th1 responses in healthy individuals. The impairment of these responses in CD and AS patients might be due to recruitment of enterobacteria-specific Th1 cells to the gut or might reflect inadequate priming of adaptive immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.