Evidence map›Paper›PMID 21901389›Full record

Trial reportBreast cancer research and treatment2012

The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial.

Virginia P Henderson, Lynn Clemow, Ann O Massion, Thomas G Hurley, Susan Druker, James R Hébert

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 21 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 21 syntheses or guidelines pooled it.

  1. Resilience interventions for stress-related health outcomes in patients with cancer: Findings from a systematic review of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  4. Psychological interventions for women with non-metastatic breast cancer.The Cochrane database of systematic reviews · 2023
    Pooled it
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  8. Recommendations for spiritual care in cancer patients: a clinical practice guideline for oncology nurses in Iran.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  9. The effectiveness of mindfulness-based interventions among cancer patients and survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
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  12. Mindfulness-based stress reduction for women diagnosed with breast cancer.The Cochrane database of systematic reviews · 2019
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  14. Guideline
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  17. Guideline
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  19. Breast cancer and coping among women of color: a systematic review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Pooled it
  20. Pooled it

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Virginia P HendersonDepartment of Family and Preventive Medicine, School of Medicine, University of South Carolina, 3209 Colonial Drive, Columbia, SC 29203, USA.
Lynn Clemow
Ann O Massion
Thomas G Hurley
Susan Druker
James R Hébert

Funding

Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
NCI NIH HHS K05 CA136975
6 · The paper itself

Abstract

The aim of this study was determine the effectiveness of a mindfulness-based stress-reduction (MBSR) program on quality of life (QOL) and psychosocial outcomes in women with early-stage breast cancer, using a three-arm randomized controlled clinical trial (RCT). This RCT consisting of 172 women, aged 20-65 with stage I or II breast cancer consisted of the 8-week MBSR, which was compared to a nutrition education program (NEP) and usual supportive care (UC). Follow-up was performed at three post-intervention points: 4 months, 1, and 2 years. Standardized, validated self-administered questionnaires were adopted to assess psychosocial variables. Statistical analysis included descriptive and regression analyses incorporating both intention-to-treat and post hoc multivariable approaches of the 163 women with complete data at baseline, those who were randomized to MBSR experienced a significant improvement in the primary measures of QOL and coping outcomes compared to the NEP, UC, or both, including the spirituality subscale of the FACT-B as well as dealing with illness scale increases in active behavioral coping and active cognitive coping. Secondary outcome improvements resulting in significant between-group contrasts favoring the MBSR group at 4 months included meaningfulness, depression, paranoid ideation, hostility, anxiety, unhappiness, and emotional control. Results tended to decline at 12 months and even more at 24 months, though at all times, they were as robust in women with lower expectation of effect as in those with higher expectation. The MBSR intervention appears to benefit psychosocial adjustment in cancer patients, over and above the effects of usual care or a credible control condition. The universality of effects across levels of expectation indicates a potential to utilize this stress reduction approach as complementary therapy in oncologic practice.

Indexed as

Adaptation, PsychologicalAdultAgedBreast NeoplasmsFemaleHumansMeditationMiddle AgedMind-Body Relations, MetaphysicalQuality of LifeRelaxation TherapySelf CareSocial SupportStress, PsychologicalSurveys and QuestionnairesTreatment Outcome

Identifiers

PMID21901389
PMCPMC3784652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.