ReviewRheumatology international2012
Bone marrow lesions: a universal bone response to injury?
Review in Rheumatology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Clinical performance of [European journal of nuclear medicine and molecular imaging · 2026Article
- [Subchondral insufficiency fractures of the knee : Navigating the complex terminology landscape].Radiologie (Heidelberg, Germany) · 2026Review
- Subchondral Phosphate Injection During Hip Arthroscopy Safely Treats Acetabular Bone Marrow Lesions in Early Osteoarthritis.Journal of clinical medicine · 2025Article
- [Etiology of osteonecrosis and bone marrow edema].Orthopadie (Heidelberg, Germany) · 2025Review
- Bone marrow lesion and medial meniscus extrusion width changes following arthroscopic partial meniscectomy for medial meniscal flap tears.Journal of orthopaedic surgery and research · 2025Article
- Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis.Scientific reports · 2025Article
- Bone marrow edema of the hip: a narrative review.Archives of orthopaedic and trauma surgery · 2023Review
- Article
- Tissue Integration of Calcium Phosphate Compound after Subchondroplasty: 4-Year Follow-Up in a 76-Year-Old Female Patient.Bioengineering (Basel, Switzerland) · 2023Article
- Subchondral insufficiency fracture of the knee: review of current concepts and radiological differential diagnoses.Japanese journal of radiology · 2022Review
- Percussion test: description and diagnostic accuracy of a new manual test for bone marrow edema of the knee.BMC musculoskeletal disorders · 2022Observational
- Comparison of Calcaneal Subchondral Injection of Calcium Phosphate and Plantar Fasciotomy vs Plantar Fasciotomy Alone for Refractory Infracalcaneal Heel Pain.Foot & ankle orthopaedics · 2021Article
- Percutaneous Skeletal Fixation of Painful Subchondral Bone Marrow Edema of the Knee.Arthroscopy, sports medicine, and rehabilitation · 2020Article
- Arthroscopic-Assisted Intraosseous Bioplasty of the Acetabulum.Arthroscopy techniques · 2020Article
- Transient osteoporosis of the hip and subclinical hypothyroidism: an unusual dangerous duet? Case report and pathogenetic hypothesis.BMC musculoskeletal disorders · 2020Article
- Clinical effect of intramuscular calcitonin compared with oral celecoxib in the treatment of knee bone marrow lesions: a retrospective study.Journal of orthopaedic surgery and research · 2020Article
- Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays.International journal of rheumatic diseases · 2020Article
- Short-Term Outcomes for the Biologic Treatment of Bone Marrow Edema of the Knee Using Bone Marrow Aspirate Concentrate and Injectable Demineralized Bone Matrix.Arthroscopy, sports medicine, and rehabilitation · 2019Article
- Surgical Treatment of Insufficiency Fractures of the Knee.Arthroscopy techniques · 2019Article
- Hitting the Mark: Optimizing the Use of Calcium Phosphate Injections for the Treatment of Bone Marrow Lesions of the Proximal Tibia and Distal Femur.Arthroscopy techniques · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ever increasing use of magnetic resonance imaging in clinical practice has led to the recognition of a new entity, bone marrow lesions (BMLs). These lesions are characterized by excessive water signals in the marrow space and have emerged as a central component of many different diseases affecting the musculoskeletal system. BMLs have in particular been associated with a wide variety of inflammatory and non-inflammatory rheumatologic conditions and are not only considered significant sources of pain, but also linked to the worsening of patient prognosis in many disease states. In this review, we summarize the current knowledge on BMLs with an emphasis on the clinical and histological features of this entity in inflammatory and non-inflammatory disease and provide a unifying hypothesis based on the appearance with various imaging technologies. We also try to pair this hypothesis with the apparent beneficial effects of various treatment regimens, mainly within the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms associated with BMLs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.