ArticlePsychopharmacology2012
D₁ receptor activation improves vigilance in rats as measured by the 5-choice continuous performance test.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Amphetamine improves mouse and human attention in the 5-choice continuous performance test.Neuropharmacology · 2018Trial
- Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.Neuropharmacology · 2017Trial
- Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats.Fundamental & clinical pharmacology · 2026Article
- Clustering Cortical Rhythms: Monoaminergic Signatures in Time-Frequency EEG Dynamics.Biomedicines · 2025Article
- Consumption of dopamine receptor 1 agonist SKF-38393 reduces constant-light-induced hyperactivity, depression-like, and anxiety-like behaviors in a sex specific manner in C57BL/6J mice.Frontiers in behavioral neuroscience · 2025Article
- Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a DPsychopharmacology · 2021Article
- Amphetamine improves rat 5-choice continuous performance test (5C-CPT) irrespective of concurrent low-dose haloperidol treatment.Psychopharmacology · 2020Article
- Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT.Bipolar disorders · 2020Article
- Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task.Psychopharmacology · 2018Article
- Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.Translational psychiatry · 2018Article
- Neurophysiological Characterization of Attentional Performance Dysfunction in Schizophrenia Patients in a Reverse-Translated Task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges.Psychopharmacology · 2016Article
- Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding.Behavioural brain research · 2016Article
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.Journal of psychopharmacology (Oxford, England) · 2015Review
- Sleep deprivation impairs performance in the 5-choice continuous performance test: similarities between humans and mice.Behavioural brain research · 2014Article
- Article
- Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task.Frontiers in neural circuits · 2014Review
- Reverse translation of the rodent 5C-CPT reveals that the impaired attention of people with schizophrenia is similar to scopolamine-induced deficits in mice.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
rationaleImpaired attention/vigilance is putatively core to schizophrenia. The dopaminergic D(1) receptor system has been reported as one of the most promising targets for improving cognition in patients with schizophrenia, with some evidence suggesting D(1) activation may improve sustained attention.
objectivesThe purpose of this study was twofold: firstly assessing the applicability of using rats in the 5-Choice Continuous Performance Test (5 C-CPT), recently validated in mice. Secondly, the effect of systemic administration of a D(1) partial agonist, SKF 38393, on task performance during baseline, and a challenge session consisting of a reduced event-rate was investigated.
methodsAnimals were trained to perform the 5 C-CPT with performance assessed following systemic SKF 38393 (2, 4 and 6 mg/kg) vs. vehicle administration.
resultsRats could discriminate between target (requiring a response) and non-target (requiring the inhibition of response) trials within the 5 C-CPT. Moreover, SKF 38393 treatment impaired performance during the baseline session reducing target detection, yet improved performance during the reduced event-rate challenge session, increasing target detection and improving signal discrimination indicating an SKF 38393-induced enhancement of vigilance. Thus, these data suggest that activation of the D(1) system affected 5 C-CPT performance in a baseline dependent manner.
conclusionRats can be trained to perform the 5 C-CPT, appropriately withholding from responding to non-target trials. Systemic administration of SKF 38393 impaired performance during baseline conditions. Following a task-related challenge, which reduced the event rate, activation of the dopamine (DA) D(1) system improved performance by heightening the animals' vigilance levels, quantified using signal detection theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.