Trial reportEuropean journal of applied physiology2012
Strength training elevates HSP27, HSP70 and αB-crystallin levels in musculi vastus lateralis and trapezius.
Trial report in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Muscular HSP70 content is higher in elderly compared to young, but is normalized after 12 weeks of strength training.European journal of applied physiology · 2021Trial
- Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways.American journal of physiology. Endocrinology and metabolism · 2021Trial
- Trial
- Unveiling the role of exercise in modulating plasma heat shock protein 27 levels: insights for exercise immunology and cardiovascular health.Molecular and cellular biochemistry · 2025Review
- The role of different exercises in irisin, heat shock protein 70 and some biochemical parameters.Journal of medical biochemistry · 2022Article
- Alpha B-Crystallin in Muscle Disease Prevention: The Role of Physical Activity.Molecules (Basel, Switzerland) · 2022Review
- Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults.Antioxidants (Basel, Switzerland) · 2021Article
- Exercise combined with trimetazidine improves anti-fatal stress capacity through enhancing autophagy and heat shock protein 70 of myocardium in mice.International journal of medical sciences · 2021Article
- The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features.Redox biology · 2019Article
- Exercise-induced bronchoconstriction, temperature regulation and the role of heat shock proteins in non-asthmatic recreational marathon and half-marathon runners.Scientific reports · 2019Article
- Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion.Frontiers in physiology · 2019Article
- Vitamin C and E supplementation does not affect heat shock proteins or endogenous antioxidants in trained skeletal muscles during 12 weeks of strength training.BMC nutrition · 2017Article
- Molecular signatures of differential responses to exercise trainings during rehabilitation.Biomedical genetics and genomics · 2017Article
- Effect of resistance exercise training on expression of Hsp70 and inflammatory cytokines in skeletal muscle and adipose tissue of STZ-induced diabetic rats.Cell stress & chaperones · 2016Article
- The effect of strength training on muscle cellular stress in prostate cancer patients on ADT.Endocrine connections · 2016Article
- The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion.European journal of applied physiology · 2013Article
- Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training.Sports medicine (Auckland, N.Z.) · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A single bout of high-force exercise has been shown to increase the muscle levels of heat shock proteins (HSPs). Here, changes in the levels of HSPs after 2 and 11 weeks of strength training with either one or three sets per exercise were examined. Fifteen young men (27 ± 6 years, 182 ± 8 cm and 82 ± 13 kg) were randomized to train either one set in lower-body exercises and three sets in upper-body exercises (1L-3UB), or three sets in lower-body exercises and one set in upper-body exercises (3L-1UB). Biopsies from vastus lateralis and trapezius were obtained before, during (2 weeks) and after 11 weeks of strength training (3 bouts per week). The biopsies were analysed for HSP27 (cytosolic and cytoskeletal fractions) and HSP70 and αB-crystallin (cytosolic fraction). No evidence for an effect of training volume (1 vs. 3 sets) on the HSP response was found. For all subjects combined, HSP27 [186 ± 69% (mean ± SD)], HSP70 (146 ± 51%) and αB-crystallin (184 ± 82%) increased in the cytosolic fraction of vastus lateralis after 11 weeks of training. In the trapezius, the only observed increase was for HSP27 in the cytosolic fraction after 2 weeks of training (149 ± 59%). However, the trapezius contained somewhat higher levels of HSP70 and αB-crystallin than vastus lateralis at baseline. The HSP27 levels in the cytoskeletal compartment did not increase significantly in either muscle. In conclusion, strength training resulted-independent of training volume-in elevated levels of HSP27, HSP70 and αB-crystallin in the cytosolic compartment of the vastus lateralis. In the trapezius, only the cytosolic HSP27 levels were increased with training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.