ArticlePloS one2011
Mediator subunit 12 is required for neutrophil development in zebrafish.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- The subunit composition of the mammalian Mediator complex is not conserved in all vertebrates: Insights from evolutionary plasticity of fish genomes.Protein science : a publication of the Protein Society · 2026Article
- MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots.Stem cells and development · 2022Article
- Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress.Microorganisms · 2021Review
- Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies.Signal transduction and targeted therapy · 2021Review
- Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.Communications biology · 2020Article
- A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia.Scientific reports · 2017Article
- MED12 in hematopoietic stem cells-cell specific function despite ubiquitous expression.Stem cell investigation · 2017Article
- There will be blood: hematopoiesis control by mediator subunit MED12.Stem cell investigation · 2017Article
- MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.Cell stem cell · 2016Article
- The Mediator of Hematopoietic Stem Cell Homeostasis.Cell stem cell · 2016Article
- A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.Molecular and cellular biology · 2015Article
- Mediator kinase module and human tumorigenesis.Critical reviews in biochemistry and molecular biology · 2015Review
- Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish.Experimental hematology · 2014Review
- Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.The Journal of biological chemistry · 2014Article
- Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.British journal of cancer · 2012Article
- Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models.Advances in hematology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptional machinery and enhancer bound regulatory factors. We have identified a new zebrafish med12 allele, syr, with a single missense mutation causing a valine to aspartic acid change at position 1046. Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.