ArticlePLoS genetics2011
Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- A genetic strategy to measure insulin signaling regulation and physiology in Drosophila.PLoS genetics · 2023Article
- Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway.PLoS genetics · 2022Article
- Review
- Insects as a New Complex Model in Hormonal Basis of Obesity.International journal of molecular sciences · 2021Review
- Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila.Cell metabolism · 2021Review
- The Glucagon-Like Adipokinetic Hormone inFrontiers in physiology · 2021Review
- Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions.Cell and tissue research · 2020Review
- Regulation of insulin and adipokinetic hormone/glucagon production in flies.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Glass confers rhabdomeric photoreceptor identity inEvoDevo · 2019Article
- Article
- A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research.G3 (Bethesda, Md.) · 2016Article
- The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation.Cell reports · 2016Article
- Suppression of insulin production and secretion by a decretin hormone.Cell metabolism · 2015Article
- A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion.PLoS genetics · 2014Article
- Gut insulin from Foxo1 loss.Nature genetics · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic α-cells. Although Drosophila CC cells have been regarded as developmental orthologues of pituitary gland, the genetic regulation of CC development is poorly understood. From a genetic screen, we identified multiple novel regulators of CC development, including Notch signaling factors. Our studies demonstrate that the disruption of Notch signaling can lead to the expansion of CC cells. Live imaging demonstrates localized emergence of extra precursor cells as the basis of CC expansion in Notch mutants. Contrary to a recent report, we unexpectedly found that CC cells originate from head mesoderm. We show that Tinman expression in head mesoderm is regulated by Notch signaling and that the combination of Daughterless and Tinman is sufficient for ectopic CC specification in mesoderm. Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism.
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