ArticlePLoS pathogens2011
Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors.
Article in PLoS pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 182 citations in OpenAlex.
- Regulatory role of epigenetics in rice immunity against bacterial and fungal pathogens.Crop health · 2026Review
- Transcriptomic Profiling of Host Responses Underlying Synergistic Interaction Between the Phloem-Limited Brassica Yellows Virus and Pea Enation Mosaic Virus 2 inPlants (Basel, Switzerland) · 2026Article
- Small RNA mobility and plant virus diseases.Journal of experimental botany · 2026Review
- Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption.BMC genomics · 2025Article
- A plant bunyaviral protein disrupts SERRATE phase separation to modulate microRNA biogenesis during viral pathogenesis.Nature communications · 2025Article
- Article
- MicroRNA-Mediated Post-Transcriptional Regulation of Enzymes Involved in Herbicide Resistance inPlants (Basel, Switzerland) · 2025Article
- Transcriptome analysis reveals a lncRNA-miRNA-mRNA regulatory network in OsRpp30-mediated disease resistance in rice.BMC genomics · 2023Article
- Cytological, transcriptome and miRNome temporal landscapes decode enhancement of rice grain size.BMC biology · 2023Article
- A Novel miRNA in Rice Associated with the Low Seed Setting Rate Symptom of Rice Stripe Virus.International journal of molecular sciences · 2023Article
- Transcriptional and post-transcriptional regulation of RNAi-related gene expression during plant-virus interactions.Stress biology · 2022Review
- Analyses on the Infection Process of Rice Virus and the Spatiotemporal Expression Pattern of Host Defense Genes Based on a Determined-Part Inoculation Approach.Pathogens (Basel, Switzerland) · 2022Article
- Identification and characterization of miRNAome and target genes in Pseudostellaria heterophylla.PloS one · 2022Article
- miR160: An Indispensable Regulator in Plant.Frontiers in plant science · 2022Review
- Roles of small RNAs in crop disease resistance.Stress biology · 2021Review
- MicroRNAs: Potential Targets for Developing Stress-Tolerant Crops.Life (Basel, Switzerland) · 2021Review
- Contribution of Small RNA Pathway to Interactions of Rice with Pathogens and Insect Pests.Rice (New York, N.Y.) · 2021Review
- Article
- The Epstein-Barr Virus-Encoded EBNA1 Protein Activates the Bone Morphogenic Protein (BMP) Signalling Pathway to Promote Carcinoma Cell Migration.Pathogens (Basel, Switzerland) · 2020Article
- Suppression of nbe-miR1919c-5p Expression inViruses · 2020Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing, mediated by small RNAs including microRNAs (miRNAs) and small interfering RNAs (siRNAs), is a potent antiviral or antibacterial mechanism, besides regulating normal cellular gene expression critical for development and physiology. To gain insights into host small RNA metabolism under infections by different viruses, we used Solexa/Illumina deep sequencing to characterize the small RNA profiles of rice plants infected by two distinct viruses, Rice dwarf virus (RDV, dsRNA virus) and Rice stripe virus (RSV, a negative sense and ambisense RNA virus), respectively, as compared with those from non-infected plants. Our analyses showed that RSV infection enhanced the accumulation of some rice miRNA*s, but not their corresponding miRNAs, as well as accumulation of phased siRNAs from a particular precursor. Furthermore, RSV infection also induced the expression of novel miRNAs in a phased pattern from several conserved miRNA precursors. In comparison, no such changes in host small RNA expression was observed in RDV-infected rice plants. Significantly RSV infection elevated the expression levels of selective OsDCLs and OsAGOs, whereas RDV infection only affected the expression of certain OsRDRs. Our results provide a comparative analysis, via deep sequencing, of changes in the small RNA profiles and in the genes of RNA silencing machinery induced by different viruses in a natural and economically important crop host plant. They uncover new mechanisms and complexity of virus-host interactions that may have important implications for further studies on the evolution of cellular small RNA biogenesis that impact pathogen infection, pathogenesis, as well as organismal development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.