ArticlePLoS computational biology2011
Towards a system level understanding of non-model organisms sampled from the environment: a network biology approach.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 89 citations in OpenAlex.
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- Correlations between oxidative DNA damage and formation of hepatic tumours in two flatfish species from contaminated environments.Biology letters · 2023Article
- The Eco-Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals.Environmental toxicology and chemistry · 2022Article
- Review
- Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?International journal of molecular sciences · 2021Review
- An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary.Journal of xenobiotics · 2020Article
- Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment.Integrated environmental assessment and management · 2018Article
- Tissue-Based Mapping of the Fathead Minnow (Frontiers in endocrinology · 2018Article
- Conserved Transcription Factors Steer Growth-Related Genomic Programs in Daphnia.Genome biology and evolution · 2017Article
- Changing expression of vertebrate immunity genes in an anthropogenic environment: a controlled experiment.BMC evolutionary biology · 2016Article
- Seasonal immunoregulation in a naturally-occurring vertebrate.BMC genomics · 2016Article
- Immunology in wild nonmodel rodents: an ecological context for studies of health and disease.Parasite immunology · 2015Review
- Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.BMC genomics · 2014Article
- Responses of the European flounder (Platichthys flesus) to a mixture of PAHs and PCBs in experimental conditions.Environmental science and pollution research international · 2014Article
- Transcriptome-metabolome wide association study (TMWAS) of maneb and paraquat neurotoxicity reveals network level interactions in toxicologic mechanism.Toxicology reports · 2014Article
- Bioremediation in marine ecosystems: a computational study combining ecological modeling and flux balance analysis.Frontiers in genetics · 2014Article
- Histopathological lesions and DNA adducts in the liver of European flounder (Platichthys flesus) collected in the Seine estuary versus two reference estuarine systems on the French Atlantic coast.Environmental science and pollution research international · 2013Article
- Variation patterns in individual fish responses to chemical stress among estuaries, seasons and genders: the case of the European flounder (Platichthys flesus) in the Bay of Biscay.Environmental science and pollution research international · 2013Article
- Transcriptomics responses in marine diatom Thalassiosira pseudonana exposed to the polycyclic aromatic hydrocarbon benzo[a]pyrene.PloS one · 2011Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 3 countries.
Funding
Abstract
The acquisition and analysis of datasets including multi-level omics and physiology from non-model species, sampled from field populations, is a formidable challenge, which so far has prevented the application of systems biology approaches. If successful, these could contribute enormously to improving our understanding of how populations of living organisms adapt to environmental stressors relating to, for example, pollution and climate. Here we describe the first application of a network inference approach integrating transcriptional, metabolic and phenotypic information representative of wild populations of the European flounder fish, sampled at seven estuarine locations in northern Europe with different degrees and profiles of chemical contaminants. We identified network modules, whose activity was predictive of environmental exposure and represented a link between molecular and morphometric indices. These sub-networks represented both known and candidate novel adverse outcome pathways representative of several aspects of human liver pathophysiology such as liver hyperplasia, fibrosis, and hepatocellular carcinoma. At the molecular level these pathways were linked to TNF alpha, TGF beta, PDGF, AGT and VEGF signalling. More generally, this pioneering study has important implications as it can be applied to model molecular mechanisms of compensatory adaptation to a wide range of scenarios in wild populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.