ArticleMolecules (Basel, Switzerland)2011
Synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
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- Biological Evaluation and Structural Analysis of Some Aminodiphenylamine Derivatives.Antioxidants (Basel, Switzerland) · 2023Article
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- Low concentrations of local honey modulate Exotoxin A expression, and quorum sensing related virulence in drug-resistantIranian journal of basic medical sciences · 2019Article
- Antimicrobial Activity of New Materials Based on Lavender and Basil Essential Oils and Hydroxyapatite.Nanomaterials (Basel, Switzerland) · 2018Article
- Properties of Basil and Lavender Essential Oils Adsorbed on the Surface of Hydroxyapatite.Materials (Basel, Switzerland) · 2018Article
- Development and Biocompatibility Evaluation of Photocatalytic TiO₂/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes.Nanomaterials (Basel, Switzerland) · 2017Article
- Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials.Nanomaterials (Basel, Switzerland) · 2017Article
- 3,4,5-Trichloroaniline nephrotoxicity in vitro: potential role of free radicals and renal biotransformation.International journal of molecular sciences · 2014Article
- Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies.Bioinorganic chemistry and applications · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy and tested for their interaction with bacterial cells in free and adherent state. The anti-pathogenic activity was correlated with the presence of one iodine, bromide or fluorine, and two or three chloride atoms on the N-phenyl substituent of the thiourea moiety, being significant especially on Pseudomonas aeruginosa and Staphylococcus aureus strains, known for their ability to grow in biofilms. Our results demonstrate the potential of these derivatives for further development of novel anti-microbial agents with antibiofilm properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.