Trial reportMedicine and science in sports and exercise2012
Predicting maximal HR in heart failure patients on β-blockade therapy.
Trial report in Medicine and science in sports and exercise, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial.European heart journal · 2013Trial
- Predictive Equation for Peak Heart Rate and First Ventilatory Threshold Heart Rate in Patients With Coronary Heart Disease.Cardiology research and practice · 2026Article
- Using Free-Living Heart Rate Data as an Objective Method to Assess Physical Activity: A Scoping Review and Recommendations by the INTERLIVE-Network Targeting Consumer Wearables.Sports medicine (Auckland, N.Z.) · 2025Article
- Old and new equations for maximal and anaerobic threshold heart rate prediction in coronary heart disease in Chinese population.BMC cardiovascular disorders · 2024Article
- Exercise intensity prescription in cardiovascular rehabilitation: bridging the gap between best evidence and clinical practice.Frontiers in cardiovascular medicine · 2024Review
- 2023 TAMIS/TSOC/TACVPR Consensus Statement for Patients with Acute Myocardial Infarction Rehabilitation.Acta Cardiologica Sinica · 2023Article
- Estimating VOInternational journal of general medicine · 2022Article
- Harnessing Neuroplasticity to Promote Brain Health in Aging Adults: Protocol for the MOVE-Cog Intervention Study.JMIR research protocols · 2021Article
- Optimizing Outcomes in Cardiac Rehabilitation: The Importance of Exercise Intensity.Frontiers in cardiovascular medicine · 2021Review
- Article
- Predictors of Exercise Capacity in Patients with Hypertrophic Obstructive Cardiomyopathy.Journal of clinical medicine · 2018Article
- Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction.ESC heart failure · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeStandards for estimating maximal HR are important when interpreting the adequacy of physiologic stress during exercise testing, assessing chronotropic response, and prescribing an exercise training regimen. The equation 220 - age is used to estimate maximum HR; however, it overestimates measured maximal HR in patients taking β-adrenergic blockade (βB) therapy. This study developed and validated a practical equation to predict maximal HR in patients with heart failure (HF) taking βB therapy.
methodsData from symptom-limited exercise tests completed on patients with systolic HF participating in the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training trial and taking a βB agent were used to develop a simplified equation, which was validated using bootstrapping.
resultsThe simplified derived equation was 119 + 0.5 (resting HR) - 0.5 (age) - (0, if test was completed using a treadmill; 5, if using a stationary bike). The R2 and SEE were 0.28 and 18 beats·min(-1), respectively. Validation of this equation yielded a mean R and SEE of 0.28 and 18 beats·min(-1), respectively. For the equation 220 - age, the R2 was -2.93, and the SEE was 43 beats·min(-1).
conclusionsWe report a valid and simple population-specific equation for estimating peak HR in patients with HF taking βB therapy. This equation should be helpful when evaluating chronotropic response or assessing if a maximum effort was provided during exercise testing. We caution, however, that the magnitude of the variation (SEE = 18 beats·min(-1)) associated with this prediction equation may make it impractical when prescribing exercise intensity.
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