ArticleProceedings of the National Academy of Sciences of the United States of America2011
Extensive changes to alternative splicing patterns following allopolyploidy in natural and resynthesized polyploids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- Transcript isoforms and alternative splicing in polyploid Brassica napus under heat and cold stress.Annals of botany · 2026Article
- Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution ofPlants (Basel, Switzerland) · 2025Article
- The Role of Alternative Splicing in Polyploids in Response to Abiotic Stress.International journal of molecular sciences · 2025Review
- Detection of Different Patterns of Genome-Wide Gene Expression Disturbance in Three Nullisomy Lines in AllotetraploidPlants (Basel, Switzerland) · 2025Article
- Article
- Defining autopolyploidy: Cytology, genetics, and taxonomy.American journal of botany · 2024Review
- Transcriptome Shock in Developing Embryos of aInternational journal of molecular sciences · 2023Article
- Deciphering complex reticulate evolution of Asian Buddleja (Scrophulariaceae): insights into the taxonomy and speciation of polyploid taxa in the Sino-Himalayan region.Annals of botany · 2023Article
- The Abundant and Unique Transcripts and Alternative Splicing of the Artificially Autododecaploid London Plane (International journal of molecular sciences · 2023Article
- Global transcriptome analysis of allopolyploidization reveals large-scale repression of the D-subgenome in synthetic hexaploid wheat.Communications biology · 2023Article
- Asymmetric gene expression in grain development of reciprocal crosses between tetraploid and hexaploid wheats.Communications biology · 2022Article
- Genetic and Physiological Responses to Heat Stress inFrontiers in plant science · 2022Review
- Phylotranscriptomics Illuminates the Placement of Whole Genome Duplications and Gene Retention in Ferns.Frontiers in plant science · 2022Article
- Development of a Prognostic Alternative Splicing Signature Associated With Tumor Microenvironment Immune Profiles in Lung Adenocarcinoma.Frontiers in oncology · 2022Article
- Genome-Wide Identification of Direct Targets of ZjVND7 Reveals the Putative Roles of Whole-Genome Duplication in Sour Jujube in Regulating Xylem Vessel Differentiation and Drought Tolerance.Frontiers in plant science · 2022Article
- Unveiling the transcriptomic complexity of Miscanthus sinensis using a combination of PacBio long read- and Illumina short read sequencing platforms.BMC genomics · 2021Article
- Transcriptome analysis reveals the molecular mechanisms of heterosis on thermal resistance in hybrid abalone.BMC genomics · 2021Article
- DNA repair- and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.).Horticulture research · 2021Article
- Multiple responses contribute to the enhanced drought tolerance of the autotetraploid Ziziphus jujuba Mill. var. spinosa.Cell & bioscience · 2021Article
- The Transcriptional and Splicing Changes Caused by Hybridization Can Be Globally Recovered by Genome Doubling during Allopolyploidization.Molecular biology and evolution · 2021Article
5 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Polyploidy has been a common process during the evolution of eukaryotes, especially plants, leading to speciation and the evolution of new gene functions. Gene expression levels and patterns can change, and gene silencing can occur in allopolyploids--phenomena sometimes referred to as "transcriptome shock." Alternative splicing (AS) creates multiple mature mRNAs from a single type of precursor mRNA. Here we examined the evolution of AS patterns after polyploidy, with natural and two resynthesized allotetraploid Brassica napus lines, using RT-PCR and sequencing assays of 82 AS events in duplicated gene pairs (homeologs). Comparing the AS patterns between the two homeologs in natural B. napus revealed that many of the gene pairs show different AS patterns, with a few showing variation that was organ specific or induced by abiotic stress treatments. In the resynthesized allotetraploids, 26-30% of the duplicated genes showed changes in AS compared with the parents, including many cases of AS event loss after polyploidy. Parallel losses of many AS events after allopolyploidy were detected in the two independently resynthesized lines. More changes occurred in parallel between the two lines than changes specific to each line. The PASTICCINO gene showed partitioning of two AS events between the two homeologs in the resynthesized allopolyploids. AS changes after allopolyploidy were much more common than homeolog silencing. Our findings indicate that AS patterns can change rapidly after polyploidy, that many genes are affected, and that AS changes are an important component of the transcriptome shock experienced by new allopolyploids.
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