Evidence map›Paper›PMID 21900517›Full record

ArticleJournal of clinical microbiology2011

Three-locus identification, genotyping, and antifungal susceptibilities of medically important Trichosporon species from China.

Li-Na Guo, Meng Xiao, Fanrong Kong, Sharon C-A Chen, He Wang, Tania C Sorrell, Wei Jiang, Hong-Tao Dou, Ruo-Yu Li, Ying-Chun Xu

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Epidemiological study ofEpidemiology and infection · 2020
    Pooled it
  2. Pooled it
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  4. Review
  5. Comparative Genomic Analysis of anPolish journal of microbiology · 2024
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  7. Article
  8. Invasive Infections Due toJournal of clinical microbiology · 2019
    Article
  9. Article
  10. Infection and drug resistance · 2018
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  11. Review
  12. Article
  13. Article
  14. The first isolation ofCurrent medical mycology · 2015
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Li-Na GuoDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China.
Meng Xiao
Fanrong Kong
Sharon C-A Chen
He Wang
Tania C Sorrell
Wei Jiang
Hong-Tao Dou
Ruo-Yu Li
Ying-Chun Xu
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNThe University of Sydney · AUChinese People's Liberation Army · CNPeking University First Hospital · CNWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three reference and 45 clinical isolates of Trichosporon were analyzed by conventional phenotypic and molecular methods to determine the species and genotypes of Trichosporon isolates from China. Target loci for molecular methods included the internal transcribed spacer (ITS) region, the D1/D2 domain of the 26S rRNA gene, and the intergenic spacer 1 (IGS1) region. Identification of eight Trichosporon species was achieved, of which Trichosporon asahii was the most common. Of the sequence-based molecular methods, the one targeting the D1/D2 domain assigned 97.9% (47/48) of isolates (seven species) correctly, while tests targeting both the ITS and IGS1 regions correctly identified all 48 isolates. The commercial API 20C AUX and Vitek 2 Compact YST systems correctly identified 91.9% and 73% of isolates when their biochemical profiles were queried against those of species contained in the databases, respectively, and misidentified 63.6% and 36.4% of isolates of species that were unclaimed by the databases, respectively. The predominant genotype among T. asahii clinical isolates, genotype 4 (51.4%), is rarely found in other countries. Voriconazole and itraconazole were the most active drugs in vitro against all the Trichosporon species tested, while caspofungin and amphotericin B demonstrated poor activity.

Indexed as

Antifungal AgentsChinaCluster AnalysisDNA, FungalDNA, RibosomalDNA, Ribosomal SpacerGenes, rRNAHumansMicrobial Sensitivity TestsMolecular Sequence DataMolecular TypingMycological Typing TechniquesPhylogenyRNA, FungalRNA, RibosomalSequence Analysis, DNAAntifungal AgentsDNA, FungalDNA, RibosomalDNA, Ribosomal SpacerRNA, FungalRNA, RibosomalRNA, ribosomal, 26S

Identifiers

PMID21900517
PMCPMC3209122
OpenAlexW2120661768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.