ArticleThe Journal of infectious diseases2011
LPLUNC1 modulates innate immune responses to Vibrio cholerae.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
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- BPIFB1 promotes metastasis of hormone receptor-positive breast cancer via inducing macrophage M2-like polarization.Cancer science · 2023Article
- Effects of chitosan nanoparticles loaded with mesenchymal stem cell conditioned media on gene expression in Vibrio cholerae and Caco-2 cells.Scientific reports · 2022Article
- Intense light-elicited alveolar type 2-specific circadian PER2 protects from bacterial lung injury via BPIFB1.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- The landscape of host genetic factors involved in immune response to common viral infections.Genome medicine · 2020Article
- The landscape of host genetic factors involved in immune response to common viral infections.medRxiv : the preprint server for health sciences · 2020Article
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- Salivary proteome of a Neotropical primate: potential roles in host defense and oral food perception.PeerJ · 2020Article
- Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution.Science advances · 2019Article
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- ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism.Mucosal immunology · 2019Article
- Metaproteomics analysis of microbial diversity of human saliva and tongue dorsum in young healthy individuals.Journal of oral microbiology · 2019Article
- A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease.European journal of gastroenterology & hepatology · 2018Article
- Presence of BPIFB1 in saliva from non-obese diabetic mice.Odontology · 2018Article
- Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways.Infection and immunity · 2018Article
- Article
- O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh.Clinical and vaccine immunology : CVI · 2016Article
- Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations.American journal of human genetics · 2015Article
- Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.Infection and immunity · 2015Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundRecent studies demonstrate that long palate, lung, and nasal epithelium clone 1 protein (LPLUNC1) is involved in immune responses to Vibrio cholerae, and that variations in the LPLUNC1 promoter influence susceptibility to severe cholera in humans. However, no functional role for LPLUNC1 has been identified.
methodsWe investigated the role of LPLUNC1 in immune responses to V. cholerae, assessing its affect on bacterial growth and killing and on innate inflammatory responses to bacterial outer membrane components, including purified lipopolysaccharide (LPS) and outer membrane vesicles. We performed immunostaining for LPLUNC1 in duodenal biopsies from cholera patients and uninfected controls.
resultsLPLUNC1 decreased proinflammatory innate immune responses to V. cholerae and Escherichia coli LPS. The effect of LPLUNC1 was dose-dependent and occurred in a TLR4-dependent manner. LPLUNC1 did not affect lipoprotein-mediated TLR2 activation. Immunostaining demonstrated expression of LPLUNC1 in Paneth cells in cholera patients and controls.
conclusionsOur results demonstrate that LPLUNC1 is expressed in Paneth cells and likely plays a role in modulating host inflammatory responses to V. cholerae infection. Attenuation of innate immune responses to LPS by LPLUNC1 may have implications for the maintenance of immune homeostasis in the intestine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.