ArticlePlant physiology2011
A role for protein kinase casein kinase2 α-subunits in the Arabidopsis circadian clock.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- The G protein-casein kinase 2 module acts as a pivot in plasma membrane-to-nucleus CLAVATA signaling to control shoot apical meristem size.Nature communications · 2026Article
- CK2 kinase-PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants.Nature plants · 2025Article
- Genome scans capture key adaptation and historical hybridization signatures in tetraploid wheat.The plant genome · 2025Article
- A phospho-dawn of protein modification anticipates light onset in the picoeukaryote Ostreococcus tauri.Journal of experimental botany · 2023Article
- CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.Nucleic acids research · 2023Article
- Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders.Frontiers in molecular neuroscience · 2023Article
- Multi-omic analysis shows REVEILLE clock genes are involved in carbohydrate metabolism and proteasome function.Plant physiology · 2022Article
- Phosphorylation of OsTGA5 by casein kinase II compromises its suppression of defense-related gene transcription in rice.The Plant cell · 2022Article
- Diurnal dynamics of the Arabidopsis rosette proteome and phosphoproteome.Plant, cell & environment · 2021Article
- Review
- Crosstalk in the darkness: bulb vernalization activates meristem transition via circadian rhythm and photoperiodic pathway.BMC plant biology · 2020Article
- A Natural Variant of miR397 Mediates a Feedback Loop in Circadian Rhythm.Plant physiology · 2020Article
- Quantitative Early Auxin Root Proteomics Identifies GAUT10, a Galacturonosyltransferase, as a Novel Regulator of Root Meristem Maintenance.Molecular & cellular proteomics : MCP · 2019Article
- The Plant Circadian Oscillator.Biology · 2019Review
- Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks.Cold Spring Harbor perspectives in biology · 2018Review
- Auxin controls circadian flower opening and closure in the waterlily.BMC plant biology · 2018Article
- Characterization of the CCT family and analysis of gene expression in Aegilops tauschii.PloS one · 2017Article
- Role of vernalization-mediated demethylation in the floral transition of Brassica rapa.Planta · 2017Article
- Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock.The Plant cell · 2016Article
- A mutation of casein kinase 2 α4 subunit affects multiple developmental processes in Arabidopsis.Plant cell reports · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms are autoregulatory, endogenous rhythms with a period of approximately 24 h. A wide variety of physiological and molecular processes are regulated by the circadian clock in organisms ranging from bacteria to humans. Phosphorylation of clock proteins plays a critical role in generating proper circadian rhythms. Casein Kinase2 (CK2) is an evolutionarily conserved serine/threonine protein kinase composed of two catalytic α-subunits and two regulatory β-subunits. Although most of the molecular components responsible for circadian function are not conserved between kingdoms, CK2 is a well-conserved clock component modulating the stability and subcellular localization of essential clock proteins. Here, we examined the effects of a cka1a2a3 triple mutant on the Arabidopsis (Arabidopsis thaliana) circadian clock. Loss-of-function mutations in three nuclear-localized CK2α subunits result in period lengthening of various circadian output rhythms and central clock gene expression, demonstrating that the cka1a2a3 triple mutant affects the pace of the circadian clock. Additionally, the cka1a2a3 triple mutant has reduced levels of CK2 kinase activity and CIRCADIAN CLOCK ASSOCIATED1 phosphorylation in vitro. Finally, we found that the photoperiodic flowering response, which is regulated by circadian rhythms, was reduced in the cka1a2a3 triple mutant and that the plants flowered later under long-day conditions. These data demonstrate that CK2α subunits are important components of the Arabidopsis circadian system and their effects on rhythms are in part due to their phosphorylation of CIRCADIAN CLOCK ASSOCIATED1.
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