ArticleGenetics2011
Genetic architecture of male sterility and segregation distortion in Drosophila pseudoobscura Bogota-USA hybrids.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Selfish chromosomes exploit a germline checkpoint to eliminate competing gametes.Nature communications · 2026Article
- Review
- Article
- Beyond Haldane's rule: Sex-biased hybrid dysfunction for all modes of sex determination.eLife · 2024Review
- Article
- Transformation of meiotic drive into hybrid sterility in Drosophila.bioRxiv : the preprint server for biology · 2024Article
- Hybrid breakdown in male reproduction between recently diverged Drosophila melanogaster populations has a complex and variable genetic architecture.Evolution; international journal of organic evolution · 2023Article
- Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).Genetics · 2022Article
- Divergence of X-linked trans regulatory proteins and the misexpression of gene targets in sterile Drosophila pseudoobscura hybrids.BMC genomics · 2022Article
- Hybrid Sterility, Genetic Conflict and Complex Speciation: Lessons From theFrontiers in genetics · 2021Review
- Disrupted Gene Networks in Subfertile Hybrid House Mice.Molecular biology and evolution · 2020Article
- The genetic basis of hybrid male sterility in sympatric Primulina species.BMC evolutionary biology · 2020Article
- A common suite of cellular abnormalities and spermatogenetic errors in sterile hybrid males inProceedings. Biological sciences · 2020Article
- Genetic Dissection and Validation of Chromosomal Regions for Transmission Ratio Distortion in Intersubspecific Crosses of Rice.Frontiers in plant science · 2020Article
- Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019Article
- Testes Proteases Expression and Hybrid Male Sterility Between Subspecies ofG3 (Bethesda, Md.) · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- Ancestral polymorphisms explain the role of chromosomal inversions in speciation.PLoS genetics · 2018Article
- Contrasting patterns of X-chromosome divergence underlie multiple sex-ratio polymorphisms in stalk-eyed flies.Journal of evolutionary biology · 2017Article
- Crosses Heterozygous for Hybrid Neurospora Translocation Strains Show Transmission Ratio Distortion Disfavoring Homokaryotic Ascospores Made Following Alternate Segregation.G3 (Bethesda, Md.) · 2016Article
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1 author.
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Abstract
Understanding the genetic basis of reproductive isolation between recently diverged species is a central problem in evolutionary genetics. Here, I present analyses of the genetic architecture underlying hybrid male sterility and segregation distortion between the Bogota and USA subspecies of Drosophila pseudoobscura. Previously, a single gene, Overdrive (Ovd), was shown to be necessary but not sufficient for both male sterility and segregation distortion in F(1) hybrids between these subspecies, requiring several interacting partner loci for full manifestation of hybrid phenomena. I map these partner loci separately on the Bogota X chromosome and USA autosomes using a combination of different mapping strategies. I find that hybrid sterility involves a single hybrid incompatibility of at least seven interacting partner genes that includes three large-effect loci. Segregation distortion involves three loci on the Bogota X chromosome and one locus on the autosomes. The genetic bases of hybrid sterility and segregation distortion are at least partially--but not completely--overlapping. My results lay the foundation for fine-mapping experiments to identify the complete set of genes that interact with Overdrive. While individual genes that cause hybrid sterility or inviability have been identified in a few cases, my analysis provides a comprehensive look at the genetic architecture of all components of a hybrid incompatibility underlying F(1) hybrid sterility. Such an analysis would likely be unfeasible for most species pairs due to their divergence time and emphasizes the importance of young species pairs such as the D. pseudoobscura subspecies studied here.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.