ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Impaired B cell development and function in the absence of IkappaBNS.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025Review
- Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes.The Journal of experimental medicine · 2025Article
- NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma.Oncology letters · 2024Article
- Spatially resolved deconvolution of the fibrotic niche in lung fibrosis.Cell reports · 2022Article
- IκBFrontiers in immunology · 2022Article
- IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens.Frontiers in immunology · 2022Article
- Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii.PLoS pathogens · 2021Article
- Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.Communications biology · 2021Article
- A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation.Cancer cell · 2021Article
- NF-κB and Its Regulators During Pregnancy.Frontiers in immunology · 2021Review
- Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.Journal of virology · 2019Article
- IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production.Scientific reports · 2019Article
- TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS.Immunology and cell biology · 2019Article
- A HypermorphicJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.The Journal of clinical investigation · 2018Article
- Article
- Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.The Journal of biological chemistry · 2017Article
- The atypical IκB protein IκB(NS) is important for Toll-like receptor-induced interleukin-10 production in B cells.Immunology · 2016Article
- Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens.Frontiers in immunology · 2016Article
- Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.Molecular systems biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which undergoes induction upon TCR signaling. Mice carrying a targeted gene disruption of IκBNS demonstrate dysregulation of cytokines in T cells, macrophages, and dendritic cells. IκBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine. In this study, we demonstrate an additional role for IκBNS in the B cell lineage. B cells from IκBNS knockout (KO) mice were impaired in proliferative responses to LPS and anti-CD40. IgM and IgG3 Igs were drastically reduced in the serum of IκBNS KO mice, although IκBNS KO B cells exhibited a higher level of surface IgM than that found in wild-type mice. Switching to IgG3 was significantly reduced in IκBNS KO B cells. The in vitro induction of plasma cell development demonstrated that progression to Ab-secreting cells was impaired in IκBNS KO B cells. In agreement with this finding, the number of Ab-secreting cells in the spleens of IκBNS KO mice was reduced and production of Ag-specific Igs was lower in IκBNS KO mice after influenza infection as compared with wild-type mice. Additionally, IκBNS KO mice lacked B1 B cells and exhibited a reduction in marginal zone B cells. Thus, IκBNS significantly impacts the development and functions of B cells and plasma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.