Evidence map›Paper›PMID 21900009›Full record

ReviewTrends in cell biology2011

The ER in 3D: a multifunctional dynamic membrane network.

Jonathan R Friedman, Gia K Voeltz

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed.

  1. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Trial
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  15. In Vitro Homotypic ER Membrane Fusion Assay Using Isolated Yeast Microsomes.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan R FriedmanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA.
Gia K Voeltz

Funding

TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Reticulon Function in ER MorphologyR01GM083977 · NIGMS · UNIVERSITY OF COLORADO · PI VOELTZ, GIA · 2009 to 2017
$2.6M
NIGMS NIH HHS GM08759NIGMS NIH HHS R01 GM083977NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions.

Indexed as

AnimalsCell MembraneCell ShapeCytoskeletonEndoplasmic ReticulumEndosomesGolgi ApparatusHumansImaging, Three-DimensionalMembrane FusionMicroscopyModels, BiologicalOrganelle ShapePeroxisomes

Identifiers

PMID21900009
PMCPMC3221873

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.