ArticleBMC public health2011
Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling.
Article in BMC public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Test-adjusted estimation for pertussis incidence in greater Toronto, Canada, 1993-2006.BMC infectious diseases · 2025Article
- Proteomic comparison of epidemic AustralianMicrobiology spectrum · 2025Article
- Epidemiological characteristics and survival analysis of pertussis in Quzhou.Human vaccines & immunotherapeutics · 2024Article
- Genomic characterization ofMicrobial genomics · 2023Article
- The Present and Future Aspects of Life-Long Pertussis Prevention: Narrative Review with Regional Perspectives for Türkiye.Infectious diseases and therapy · 2023Review
- Incidence and Transmission Dynamics of Bordetella pertussis Infection in Rural and Urban Communities, South Africa, 2016‒2018.Emerging infectious diseases · 2023Article
- Pertussis epidemiology in Canada, 2005-2019.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Exploring the reasons for low pertussis vaccine effectiveness in Ontario, Canada, 2006-2008: a Canadian Immunization Research Network study.Canadian journal of public health = Revue canadienne de sante publique · 2022Article
- Clinical characteristics of 967 children with pertussis: a single-center analysis over an 8-year period in Beijing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Revisiting the epidemiology of pertussis in Canada, 1924-2015: a literature review, evidence synthesis, and modeling study.BMC public health · 2020Review
- Article
- Challenges and clinical relevance of molecular detection of Bordetella pertussis in South Africa.BMC infectious diseases · 2019Article
- Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines.Frontiers in immunology · 2019Review
- In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster.International journal of environmental research and public health · 2018Article
- Prevention of pertussis: An unresolved problem.Human vaccines & immunotherapeutics · 2018Review
- Article
- Seroprevalence of Bordetella pertussis specific Immunoglobulin G antibody levels among asymptomatic individuals aged 4 to 24 years: a descriptive cross sectional study from Sri Lanka.BMC infectious diseases · 2016Article
- The Burden of Pertussis Hospitalization in HIV-Exposed and HIV-Unexposed South African Infants.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Effectiveness of pertussis vaccination and duration of immunity.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Article
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPertussis continues to challenge medical professionals; recently described increases in incidence may be due to age-cohort effects, vaccine effectiveness, or changes in testing patterns. Toronto, Canada has recently experienced increases in pertussis incidence, and provides an ideal jurisdiction for evaluating pertussis epidemiology due to centralized testing. We evaluated pertussis trends in Toronto using all available specimen data, which allowed us to control for changing testing patterns and practices.
methodsData included all pertussis culture and PCR test records for Greater Toronto from 1993 to 2007. We estimated incidence trends using Poisson regression models; complex relationships between disease incidence and test submission were explored with vector autoregressive models.
resultsFrom 1993 to 2007, 26988 specimens were submitted for testing; 2545 (9.4%) were positive. Pertussis incidence was 2 per 100,000 from 1993 to 2004 and increased to 10 per 100,000 from 2005-2007, with a concomitant 6-fold surge in test specimen submissions after the introduction of a new, more sensitive PCR assay. The relative change in incidence was less marked after adjustment for testing volumes. Bidirectional feedbacks between test positivity and test submissions were identified.
conclusionsToronto's recent surge in pertussis reflects a true increase in local disease activity; the apparent size of the outbreak has likely been magnified by increasing use of pertussis testing by clinicians, and by improved test sensitivity since 2005. These findings may be applicable to changes in pertussis epidemiology that have been noted elsewhere in North America.
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