ArticleBehavioral and brain functions : BBF2011
Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus.
Article in Behavioral and brain functions : BBF, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Current and Emerging Therapies for Chronic Subjective Tinnitus.Journal of clinical medicine · 2023Review
- Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Article
- Genetic predisposition to tinnitus in the UK Biobank population.Scientific reports · 2021Article
- Genetic Inheritance and Its Contribution to Tinnitus.Current topics in behavioral neurosciences · 2021Review
- The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere's Disease-A Preliminary Study.The journal of international advanced otology · 2019Article
- Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus.JAMA otolaryngology-- head & neck surgery · 2019Article
- Genes important for otoneurological diagnostic purposes - current status and future prospects.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Review
- Genetics of Tinnitus: Still in its Infancy.Frontiers in neuroscience · 2017Review
- Genetics of Tinnitus: Time to Biobank Phantom Sounds.Frontiers in genetics · 2017Article
- Review
- Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.Frontiers in neuroscience · 2016Review
- KCNE3 acts by promoting voltage sensor activation in KCNQ1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Functional significance of K+ channel β-subunit KCNE3 in auditory neurons.The Journal of biological chemistry · 2014Article
- Analysis of Studies in Tinnitus-Related Gene Research.Noise & healthReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele frequencies were determined for 11 known variants of which two (F66F and R83H) were polymorphic but were not associated with the disorder. No novel variants were identified and only three carriers of R83H were noted. However, owing to a lack of power, our study can neither rule out effects of KCNE3 on the risk for developing chronic tinnitus, nor can it exclude a role in predicting the severity of tinnitus. More extensive investigations are invited, including tests for possible effects of variation in this ion channel protein on the response to treatment.
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