ArticleBioconjugate chemistry2011
Improved tumor targeting of polymer-based nanovesicles using polymer-lipid blends.
Article in Bioconjugate chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Lipid Membrane Leaflets Unzip upon Hybridization with Polymer-Rich Nanodomains.Macromolecules · 2024Article
- Advances in block copolymer-phospholipid hybrid vesicles: from physical-chemical properties to applications.Chemical science · 2024Review
- Microfluidic synthesis of multilayered lipid-polymer hybrid nanoparticles for the formulation of low solubility drugs.Soft matter · 2023Article
- Research Progress and Prospects for Polymeric Nanovesicles in Anticancer Drug Delivery.Frontiers in bioengineering and biotechnology · 2022Review
- MNPs-IHSPN nanoparticles in multi-application with absorption of bio drugs in vitro.Biochemistry and biophysics reports · 2021Article
- Polymer-Lipid Hybrid Materials.Chemical reviews · 2021Review
- Hybrid lipopolymer vesicle drug delivery and release systems.Journal of biomedical research · 2021Article
- Hybrid Vesicle Stability under Sterilisation and Preservation Processes Used in the Manufacture of Medicinal Formulations.Polymers · 2020Article
- Article
- Fluorescent Magnetopolymersomes: A Theranostic Platform to Track Intracellular Delivery.Materials (Basel, Switzerland) · 2017Article
- Durable vesicles for reconstitution of membrane proteins in biotechnology.Biochemical Society transactions · 2017Review
- Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology.Chemical communications (Cambridge, England) · 2016Article
- Mechanical Characterization of Hybrid Vesicles Based on Linear Poly(Dimethylsiloxane-b-Ethylene Oxide) and Poly(Butadiene-b-Ethylene Oxide) Block Copolymers.Sensors (Basel, Switzerland) · 2016Article
- A simple method for the synthesis of porous polymeric vesicles and their application as MR contrast agents.Journal of materials chemistry. B · 2015Article
- Phospholipid-polymer amphiphile hybrid assemblies and their interaction with macrophages.Biomicrofluidics · 2015Article
- Non-Catalyzed Click Reactions of ADIBO Derivatives with 5-Methyluridine Azides and Conformational Study of the Resulting Triazoles.PloS one · 2015Article
- Polymersome-based drug-delivery strategies for cancer therapeutics.Therapeutic delivery · 2015Review
- Facile method for the site-specific, covalent attachment of full-length IgG onto nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2014Article
- Sequential "click" - "photo-click" cross-linker for catalyst-free ligation of azide-tagged substrates.The Journal of organic chemistry · 2014Article
- Dawn of advanced molecular medicine: nanotechnological advancements in cancer imaging and therapy.Critical reviews in oncogenesis · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Block copolymer-based vesicles have recently garnered a great deal of interest as nanoplatforms for drug delivery and molecular imaging applications due to their unique structural properties. These nanovesicles have been shown to direct their cargo to disease sites either through enhanced permeability and retention or even more efficiently via active targeting. Here, we show that the efficacy of nanovesicle targeting can be significantly improved when prepared from polymer-lipid blends compared with block copolymer alone. Polymer-lipid hybrid nanovesicles were produced from the aqueous coassembly of the diblock copolymer, poly(ethylene oxide)-block-polybutadiene (PEO-PBD), and the phospholipid, hydrogenated soy phosphatidylcholine (HSPC). The PEG-based vesicles, 117 nm in diameter, were functionalized with either folic acid or anti-HER2/neu affibodies as targeting ligands to confer specificity for cancer cells. Our results revealed that nanovesicles prepared from polymer-lipid blends led to significant improvement in cell binding compared to nanovesicles prepared from block copolymer alone in both in vitro cell studies and murine tumor models. Therefore, it is envisioned that nanovesicles composed of polymer-lipid blends may constitute a preferred embodiment for targeted drug delivery and molecular imaging applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.