ArticleACS nano2011
Single-molecule detection of H₂O₂ mediating angiogenic redox signaling on fluorescent single-walled carbon nanotube array.
Article in ACS nano, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Label-free and real-time monitoring of photoaging with high spatiotemporal resolution using an nIR fluorescent nanosensor array.Science advances · 2025Article
- Recent Advances in Electrochemical Sensing of Hydrogen Peroxide (HNanomaterials (Basel, Switzerland) · 2022Review
- Biosensing with Fluorescent Carbon Nanotubes.Angewandte Chemie (International ed. in English) · 2022Review
- Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry.Nature communications · 2021Article
- Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments.Frontiers in chemistry · 2021Review
- Enzyme-free electrocatalytic sensing of hydrogen peroxide using a glassy carbon electrode modified with cobalt nanoparticle-decorated tungsten carbide.Mikrochimica acta · 2019Article
- Electrochemical Quantification of Extracellular Local HAntioxidants & redox signaling · 2018Article
- Role of Au(NPs) in the enhanced response of Au(NPs)-decorated MWCNT electrochemical biosensor.International journal of nanomedicine · 2018Article
- Gold Nanocluster Containing Polymeric Microcapsules for Intracellular Ratiometric Fluorescence Biosensing.ACS omega · 2017Article
- Single-ion adsorption and switching in carbon nanotubes.Nature communications · 2016Article
- Spatiotemporal intracellular nitric oxide signaling captured using internalized, near-infrared fluorescent carbon nanotube nanosensors.Nano letters · 2014Article
- Recent advances in hydrogen peroxide imaging for biological applications.Cell & bioscience · 2014Review
- Beyond oxidative stress: an immunologist's guide to reactive oxygen species.Nature reviews. Immunology · 2013Review
- Recent advances in intracellular and in vivo ROS sensing: focus on nanoparticle and nanotube applications.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
Reactive oxygen species, specifically hydrogen peroxide (H(2)O(2)), activate signal transduction pathways during angiogenesis and therefore play an important role in physiological development as well as various pathophysiologies. Herein, we utilize a near-infrared fluorescent single-walled carbon nanotube (SWNT) sensor array to measure the single-molecule efflux of H(2)O(2) from human umbilical vein endothelial cells (HUVEC) in response to angiogenic stimulation. Two angiogenic agents were investigated: the pro-angiogenic cytokine, vascular endothelial growth factor A (VEGF-A) and the recently identified inorganic pro-angiogenic factor, europium(III) hydroxide in nanorod form. The nanosensor array consists ofa SWNT embedded within a collagen matrix that exhibits high selectivity and sensitivity to single molecules of H(2)O(2). A calibration from 12.5 to 400 nM quantifies the production of H(2)O(2) at nanomolar concentration in HUVEC with 1 s temporal and 300 nm spatial resolutions. We find that the production of H(2)O(2) following VEGF stimulation is elevated outside of HUVEC, but not for stimulation via nanorods, while increased generation is observed in the cytoplasm for both cases, suggesting two distinct signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.