Evidence map›Paper›PMID 21898857›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Normal morphogenesis of epithelial tissues and progression of epithelial tumors.

Chun-Chao Wang, Leen Jamal, Kevin A Janes

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Physical models of embryonic epithelial healing.PLoS computational biology · 2026
    Review
  4. Article
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  6. Article
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  8. Article
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  11. Review
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  14. Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chun-Chao WangDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Leen Jamal
Kevin A Janes

Funding

Stochastic Control of Abnormal Morphogenesis Induced by the ErbB2 OncoproteinDP2OD006464 · OD · UNIVERSITY OF VIRGINIA · PI JANES, KEVIN A · 2009 to 2009
$2.3M
NIH HHS 1-DP2-OD006464-01NIH HHS DP2 OD006464
6 · The paper itself

Abstract

Epithelial cells organize into various tissue architectures that largely maintain their structure throughout the life of an organism. For decades, the morphogenesis of epithelial tissues has fascinated scientists at the interface of cell, developmental, and molecular biology. Systems biology offers ways to combine knowledge from these disciplines by building integrative models that are quantitative and predictive. Can such models be useful for gaining a deeper understanding of epithelial morphogenesis? Here, we take inventory of some recurring themes in epithelial morphogenesis that systems approaches could strive to capture. Predictive understanding of morphogenesis at the systems level would prove especially valuable for diseases such as cancer, where epithelial tissue architecture is profoundly disrupted.

Indexed as

MorphogenesisAnimalsApoptosisCarcinomaCell MovementCell ProliferationComputer SimulationEpitheliumExtracellular MatrixHumansIntercellular Signaling Peptides and ProteinsMiceModels, BiologicalSystems BiologyIntercellular Signaling Peptides and Proteins

Identifiers

PMID21898857
PMCPMC3242861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.