ReviewDevelopmental neurobiology2012
The ever-changing brain: cellular and molecular mechanisms for the effects of stressful experiences.
Review in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 157 citations in OpenAlex.
- Trait and state anxiety: relations to executive functioning in an at-risk sample.Cognition & emotion · 2014Trial
- Bioactive dietary polyphenols modulate hippocampal inflammasome activation and sex-specific affective behavioral deficits following peripheral Foxp3Research square · 2026Article
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- Neurocognitive effects of postbiotics from Lactobacillus and Bifidobacterium strains in a mouse model of chronic variable stress.Scientific reports · 2026Article
- Chronic Inflammation and Neuroprogression in the Pathophysiology in Major Depression.Advances in experimental medicine and biology · 2026Review
- Probiotic effects on cognitive performance, hippocampal oxidative stress, and structural damage induced by icv STZ in Alzheimer-like rat model.Brain structure & function · 2025Article
- Neurological consequences of climate change: a review of emerging challenges and potential impacts on brain health.Annals of medicine and surgery (2012) · 2025Review
- Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025Review
- Estrogen, menopause, and Alzheimer's disease: understanding the link to cognitive decline in women.Frontiers in molecular biosciences · 2025Review
- Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms.Biomedicines · 2024Review
- Investigating Whether a Combination of Electro-Encephalography and Gene Expression Profiling Can Predict the Risk of Chronic Pain: A Protocol for an Observational Prospective Cohort Study.Brain sciences · 2024Article
- Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats.Journal of molecular neuroscience : MN · 2023Article
- Effects of Group Size on Behavior, Reproduction, and mRNA Expression in Brains of Brandt's Voles.Brain sciences · 2023Article
- Electroacupuncture Alleviates 46-Trinitrobenzene Sulfonic Acid-Induced Visceral Pain via the Glutamatergic Pathway in the Prefrontal Cortex.Oxidative medicine and cellular longevity · 2023Article
- Radically reframing studies on neurobiology and socioeconomic circumstances: A call for social justice-oriented neuroscience.Frontiers in integrative neuroscience · 2022Article
- Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults.Neurobiology of stress · 2021Article
- Review
- Greater history of traumatic event exposure and PTSD associated with comorbid body dysmorphic disorder in a large OCD cohort.Psychiatry research · 2020Article
- Night-Time Shift Work and Related Stress Responses: A Study on Security Guards.International journal of environmental research and public health · 2020Article
- Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice.Molecular neuropsychiatry · 2019Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The adult brain is capable of considerable structural and functional plasticity and the study of hormone actions in brain has contributed to our understanding of this important phenomenon. In particular, stress and stress-related hormones such as glucocorticoids and mineralocorticoids play a key role in the ability of acute and chronic stress to cause reversible remodeling of neuronal connections in the hippocampus, prefrontal cortex, and amygdala. To produce this plasticity, these hormones act by both genomic and non-genomic mechanisms together with ongoing, experience-driven neural activity mediated by excitatory amino acid neurotransmitters, neurotrophic factors such as brain derived neurotrophic factor, extracellular molecules such as neural cell adhesion molecule, neuropeptides such as corticotrophin releasing factor, and endocannabinoids. The result is a dynamic brain architecture that can be modified by experience. Under this view, the role of pharmaceutical agents, such as antidepressants, is to facilitate such plasticity that must also be guided by experiences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.