ArticleDepression and anxiety2011
Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment.
Article in Depression and anxiety, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Neurodevelopmental outcome for offspring of women treated for antenatal depression: a systematic review.Archives of women's mental health · 2014Pooled it
- Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review.European child & adolescent psychiatry · 2014Pooled it
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- Evidence for neurobehavioral risk phenotypes at birth.Pediatric research · 2025Review
- Examining implications of the developmental timing of maternal trauma for prenatal and newborn outcomes.Infant behavior & development · 2023Article
- Maternal prenatal depression and epigenetic age deceleration: testing potentially confounding effects of prenatal stress and SSRI use.Epigenetics · 2021Article
- Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Meta-Analysis of Pharmacotherapy.Psychiatric research and clinical practice · 2021Review
- A common clinical conundrum: Antidepressant treatment of depression in pregnant women.Seminars in perinatology · 2020Review
- Psychosocial and medical adversity associated with neonatal neurobehavior in infants born before 30 weeks gestation.Pediatric research · 2020Article
- Neonatal Outcomes in Maternal Depression in Relation to Intrauterine Drug Exposure.Frontiers in pediatrics · 2019Article
- How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation.Current genomics · 2018Review
- Pregnancy and postpartum antidepressant use moderates the effects of sleep on depression.Archives of women's mental health · 2017Article
- New Insights into How Serotonin Selective Reuptake Inhibitors Shape the Developing Brain.Birth defects research · 2017Review
- Maternal pre-pregnancy obesity and gestational weight gain influence neonatal neurobehaviour.Maternal & child nutrition · 2017Article
- Fine Motor Differences and Prenatal Serotonin Reuptake Inhibitors Exposure.The Journal of pediatrics · 2016Article
- Antenatal depression, treatment with selective serotonin reuptake inhibitors, and neonatal brain structure: A propensity-matched cohort study.Psychiatry research. Neuroimaging · 2016Article
- The Roles of Maternal Depression, Serotonin Reuptake Inhibitor Treatment, and Concomitant Benzodiazepine Use on Infant Neurobehavioral Functioning Over the First Postnatal Month.The American journal of psychiatry · 2016Article
- Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Antenatal depression and children's developmental outcomes: potential mechanisms and treatment options.European child & adolescent psychiatry · 2014Review
- Effects of maternal psychotropic drug dosage on birth outcomes.Neuropsychiatric disease and treatment · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrenatal serotonin reuptake inhibitor (SRI) exposure has been related to adverse newborn neurobehavioral outcomes; however, these effects have not been compared to those that may arise from prenatal exposure to maternal major depressive disorder (MDD) without SRI treatment. This study examined potential effects of MDD with and without SRI treatment on newborn neurobehavior.
methodsThis was a prospective, naturalistic study. Women were seen at an outpatient research center twice during pregnancy (26-28 and 36-38 weeks gestational age (GA)). Psychiatric diagnoses were assessed using the Structured Clinical Interview for the DSM-IV; medication use was measured with the Timeline Follow-Back instrument. Three groups were established based upon MDD diagnosis and SRI use: Control (N = 56), MDD (N = 20), or MDD + SRI (N = 36). Infants were assessed on a single occasion within 3 weeks of birth with the NICU Network Neurobehavioral Assessment Scale. Generalized Linear Modeling was used to examine neurobehavioral outcomes by exposure group and infant age at assessment.
resultsFull-term infants exposed to MDD + SRIs had a lower GA than CON or MDD-exposed infants and, controlling for GA, had lower quality of movement and more central nervous system stress signs. In contrast, MDD-exposed infants had the highest quality of movement scores while having lower attention scores than CON and MDD + SRI-exposed infants.
conclusionMDD + SRI-exposed infants seem to have a different neurobehavioral profile than MDD-exposed infants in the first 3 weeks after delivery; both groups may have different neurobehavioral profiles with increasing age from birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.