ArticleThe Laryngoscope2011
Acute stress to excised vocal fold epithelium from reactive oxygen species.
Article in The Laryngoscope, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of Ferrostatin-1 on Vocal Folds in Aging Rats.The Laryngoscope · 2026Article
- Rapid expansion of primary human vocal fold epithelial cells via targeted pathway inhibition and anchorage-independent sphere culture.Cell reports methods · 2026Article
- The Effect of Oxidative Stress on the Human Voice.International journal of molecular sciences · 2024Review
- Corticosteroid-LABA inhalers increase phonation threshold pressure (PTP) and flow (PTF) in rabbits.The Laryngoscope · 2023Article
- In vivo measurement of vocal fold surface resistance.The Laryngoscope · 2017Article
- Structurally and functionally characterized in vitro model of rabbit vocal fold epithelium.Tissue & cell · 2017Article
- Utility of cell viability assays for use with ex vivo vocal fold epithelial tissue.The Laryngoscope · 2015Article
- Climate, vocal folds, and tonal languages: Connecting the physiological and geographic dots.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Vocal fold epithelial barrier in health and injury: a research review.Journal of speech, language, and hearing research : JSLHR · 2014Review
- Vocal fold ion transport and mucin expression following acrolein exposure.The Journal of membrane biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectives/hypothesisVocal fold epithelium is exposed to reactive oxygen species from the inhaled environment and from tissue inflammation. The objective of this study was to explore the functional and structural consequences of reactive oxygen species exposure on vocal fold epithelium. STUDY
designIn vitro, prospective study design.
methodsHydrogen peroxide (H(2)O(2)), a common reactive oxygen species, was utilized in this study. Freshly excised, viable porcine vocal fold epithelia (N = 32) were exposed to H(2) O(2) or sham challenge for 2 hours. Electrophysiology, western blotting, and light microscopy were used to quantify the functional and structural effects of reactive oxygen species on vocal fold epithelia.
resultsExposure to reactive oxygen species did not significantly alter transepithelial resistance. There was a small, nonsignificant trend for decreased concentration of epithelial junctional complex protein with reactive oxygen species challenge. Minimal changes to the gross structural appearance of vocal fold epithelia were also noted.
conclusionsThe stratified squamous epithelia of the vocal folds effectively defend against an acute reactive oxygen species challenge. The current study lays the groundwork for future investigations on the effects of reactive oxygen species on vocal fold epithelia that are compromised from phonotrauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.