ArticleAge (Dordrecht, Netherlands)2012
Effect of aging on islet beta-cell function and its mechanisms in Wistar rats.
Article in Age (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Investigation of Pancreatic-beta Cells Role in the Biological Process of Ageing.Endocrine, metabolic & immune disorders drug targets · 2024Review
- β cell aging and age-related diabetes.Aging · 2021Review
- Heterogeneity and Dynamics of Vasculature in the Endocrine System During Aging and Disease.Frontiers in physiology · 2021Review
- Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.Physiological reports · 2020Article
- Age Associated Changes in Transcription of Adiponectin, AdipoR1 and AdipoR2 Genes in Pancreas of Rats.Cell journal · 2020Article
- Pancreatic senescence and its clinical manifestations.Aging medicine (Milton (N.S.W)) · 2020Review
- Glycemic Patterns and Factors Associated with Post-Hemodialysis Hyperglycemia among End-Stage Renal Disease Patients undergoing Maintenance Hemodialysis.Journal of the ASEAN Federation of Endocrine Societies · 2020Article
- Isolated pancreatic islet yield and quality is inversely related to organ donor age in rats.Experimental gerontology · 2019Article
- Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system.Redox biology · 2018Article
- Senescence of Pancreas in Middle-Aged Rats with Normal Vascular Function.Annals of transplantation · 2017Article
- Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamus Regulates Age-Dependent Obesity.PloS one · 2016Article
- Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice.PloS one · 2016Article
- Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.American journal of physiology. Endocrinology and metabolism · 2015Article
- Young capillary vessels rejuvenate aged pancreatic islets.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impaired autophagic function in rat islets with aging.Age (Dordrecht, Netherlands) · 2013Article
- A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats.Age (Dordrecht, Netherlands) · 2013Article
- Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats.Disease models & mechanisms · 2013Article
- Pancreatic function, type 2 diabetes, and metabolism in aging.International journal of endocrinology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes mellitus is characterized by islet β-cell dysfunction and its incidence increases with age. However, the mechanisms underlying the effect of aging on islet β-cell function are not fully understood. We characterized β-cell function in 4-month-old (young), 14-month-old (adult), and 24-month-old (old) male Wistar rats, and found that islet β-cell function decreased gradually with age. Old rats displayed oral glucose intolerance and exhibited a decrease in glucose-stimulated insulin release (GSIR) and palmitic acid-stimulated insulin release (PSIR). Furthermore, total superoxide dismutase (T-SOD), CuZn superoxide dismutase (CuZn-SOD), and glutathione peroxidase (GSH-Px) activity decreased, whereas serum malondialdehyde (MDA) levels increased in the older rats. Moreover, we detected a significant reduction in β-cell proliferation and an increase in the frequency of apoptotic β-cells in the islets of rats in the old group. Finally, Anxa1 expression in the islets of old rats was significantly upregulated. These data provide new insights into the development of age-related β-cell dysfunction in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.