ArticlePloS one2011
Synergistic activation of cardiac genes by myocardin and Tbx5.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathyFrontiers in molecular biosciences · 2023Article
- TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death.American journal of medical genetics. Part A · 2021Article
- HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.Scientific reports · 2019Article
- Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics.International journal of bipolar disorders · 2018Article
- Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition.Cell death and differentiation · 2018Article
- Regulation of cardiac myocyte cell death and differentiation by myocardin.Molecular and cellular biochemistry · 2018Review
- Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts.The Journal of biological chemistry · 2017Article
- Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.PLoS genetics · 2017Article
- TBX5: A Key Regulator of Heart Development.Current topics in developmental biology · 2017Review
- Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.Heart failure reviews · 2016Review
- The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.Developmental cell · 2016Article
- Transdifferentiation of Fibroblasts by Defined Factors.Cellular reprogramming · 2015Review
- Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5.PloS one · 2015Article
- Myocardin in biology and disease.Journal of biomedical research · 2015Review
- Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells.Journal of the American College of Cardiology · 2014Article
- Reprogramming of human fibroblasts toward a cardiac fate.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Heavy and light roles: myosin in the morphogenesis of the heart.Cellular and molecular life sciences : CMLS · 2013Review
- Article
- miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Myocardial differentiation is associated with the activation and expression of an array of cardiac specific genes. However, the transcriptional networks that control cardiac gene expression are not completely understood. Myocardin is a cardiac and smooth muscle-specific expressed transcriptional coactivator of Serum Response Factor (SRF) and is able to potently activate cardiac and smooth muscle gene expression during development. We hypothesize that myocardin discriminates between cardiac and smooth muscle specific genes by associating with distinct co-factors. Here, we show that myocardin directly interacts with Tbx5, a member of the T-box family of transcription factors involved in the Holt-Oram syndrome. Tbx5 synergizes with myocardin to activate expression of the cardiac specific genes atrial natriuretic factor (ANF) and alpha myosin heavy chain (α-MHC), but not that of smooth muscle specific genes SM22 or smooth muscle myosin heavy chain (SM-MHC). We found that this synergistic activation of shared target genes is dependent on the binding sites for Tbx5, T-box factor-Binding Elements (TBEs). Myocardin and Tbx5 physically interact and their interaction domains were mapped to the basic domain and the coil domain of myocardin and Tbx5, respectively. Our analysis demonstrates that the Tbx5G80R mutation, which leads to the Holt-Oram syndrome in humans, failed to synergize with myocardin to activate cardiac gene expression. These data uncover a key role for Tbx5 and myocardin in establishing the transcriptional foundation for cardiac gene activation and suggest that the interaction of myocardin and Tbx5 maybe involved in cardiac development and diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.