ArticlePloS one2011
Combinations of SNPs related to signal transduction in bipolar disorder.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Gene variants for the WNT pathway are associated with severity in periodontal disease.Clinical oral investigations · 2024Article
- Boltzmann's Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders.Current neuropharmacology · 2024Review
- Genetic risk factors for ME/CFS identified using combinatorial analysis.Journal of translational medicine · 2022Article
- Systematic indication extension for drugs using patient stratification insights generated by combinatorial analytics.Patterns (New York, N.Y.) · 2022Review
- Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients.Frontiers in digital health · 2021Article
- Article
- Combinations of Genetic Variants Occurring Exclusively in Patients.Computational and structural biotechnology journal · 2017Review
- Combinations of genetic data in a study of oral cancer.Genes & cancer · 2015Article
- Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.PloS one · 2015Article
- A combination of single nucleotide polymorphisms in the 3'untranslated region of HLA-G is associated with preeclampsia.Human immunology · 2014Article
- Big data and clinicians: a review on the state of the science.JMIR medical informatics · 2014Review
- Article
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Authors and funding
13 authors.
Funding
Abstract
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission and calculated all combinations of three genotypes from the 3×803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC bipolar dataset were use for replication, 469 of the 803 SNP were present in the WTCCC dataset either directly (n = 132) or by imputation (n = 337) covering 51 of our selected genes. We found three clusters of patient-specific 3×SNP combinations in the WTCCC dataset. Different SNPs were involved in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.
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