ArticlePloS one2011
Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Larvicidal and Immunomodulatory Effects of Conidia and Blastospores ofJournal of fungi (Basel, Switzerland) · 2025Article
- Beauveria bassiana associated with a novel biomimetic hydrogel to control Aedes albopictus through lure and kill ovitraps.Pest management science · 2025Article
- Entomopathogenic Fungi as a Potential Management Tool for the Control of Urban Malaria Vector,Journal of fungi (Basel, Switzerland) · 2023Article
- Perspectives of vector management in the control and elimination of vector-borne zoonoses.Frontiers in microbiology · 2023Review
- Effectiveness of autocidal gravid trapping and chemical control in altering abundance and age structure of Aedes albopictus.Pest management science · 2022Article
- Proof of Concept of Biopolymer Based Hydrogels as Biomimetic Oviposition Substrate to Develop Tiger Mosquitoes (Bioengineering (Basel, Switzerland) · 2022Article
- From tissue engineering to mosquitoes: biopolymers as tools for developing a novel biomimetic approach to pest management/vector control.Parasites & vectors · 2022Review
- C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites.PLoS biology · 2022Article
- Multiple mosquito AMPs are needed to potentiate their antifungal effect against entomopathogenic fungi.Frontiers in microbiology · 2022Article
- Malaria-Transmitting Vectors Microbiota: Overview and Interactions WithFrontiers in microbiology · 2022Review
- Infection of the Stable Fly,Frontiers in fungal biology · 2021Article
- Discovery of Novel Entomopathogenic Fungi for Mosquito-Borne Disease Control.Frontiers in fungal biology · 2021Article
- Infection of highly insecticide-resistant malaria vector Anopheles coluzzii with entomopathogenic bacteria Chromobacterium violaceum reduces its survival, blood feeding propensity and fecundity.Malaria journal · 2020Article
- Semi-field evaluation of the cumulative effects of a "Lethal House Lure" on malaria mosquito mortality.Malaria journal · 2019Article
- Article
- The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae.Developmental and comparative immunology · 2018Article
- Strain-specific pathogenicity and subversion of phenoloxidase activity in the mosquito Aedes aegypti by members of the fungal entomopathogenic genus Isaria.Scientific reports · 2018Article
- Entomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system.PLoS neglected tropical diseases · 2018Article
- Biological control of human disease vectors: a perspective on challenges and opportunities.BioControl (Dordrecht, Netherlands) · 2018Review
- Proboscis infection route of Beauveria bassiana triggers early death of Anopheles mosquito.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Rapidly emerging insecticide resistance is creating an urgent need for new active ingredients to control the adult mosquitoes that vector malaria. Biopesticides based on the spores of entomopathogenic fungi have shown considerable promise by causing very substantial mortality within 7-14 days of exposure. This mortality will generate excellent malaria control if there is a high likelihood that mosquitoes contact fungi early in their adult lives. However, where contact rates are lower, as might result from poor pesticide coverage, some mosquitoes will contact fungi one or more feeding cycles after they acquire malaria, and so risk transmitting malaria before the fungus kills them. Critics have argued that 'slow acting' fungal biopesticides are, therefore, incapable of delivering malaria control in real-world contexts. Here, utilizing standard WHO laboratory protocols, we demonstrate effective action of a biopesticide much faster than previously reported. Specifically, we show that transient exposure to clay tiles sprayed with a candidate biopesticide comprising spores of a natural isolate of Beauveria bassiana, could reduce malaria transmission potential to zero within a feeding cycle. The effect resulted from a combination of high mortality and rapid fungal-induced reduction in feeding and flight capacity. Additionally, multiple insecticide-resistant lines from three key African malaria vector species were completely susceptible to fungus. Thus, fungal biopesticides can block transmission on a par with chemical insecticides, and can achieve this where chemical insecticides have little impact. These results support broadening the current vector control paradigm beyond fast-acting chemical toxins.
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