ArticleFrontiers in neural circuits2011
Delta Protocadherin 10 is Regulated by Activity in the Mouse Main Olfactory System.
Article in Frontiers in neural circuits, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- MicNet: integrating spatially resolved transcriptomes and pathology images by contrastive deep neural network.Genome biology · 2026Article
- Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb.PLoS genetics · 2026Article
- Cholinergic Waves Have a Modest Influence on the Transcriptome of Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons.Open biology · 2024Article
- Shaping the olfactory map: cell type-specific activity patterns guide circuit formation.Frontiers in neural circuits · 2024Review
- Article
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- The role of Pcdh10 in neurological disease and cancer.Journal of cancer research and clinical oncology · 2023Review
- Developing and maintaining a nose-to-brain map of odorant identity.Open biology · 2022Review
- Notch DosageFrontiers in cell and developmental biology · 2020Article
- Jagged1 is Essential for Radial Glial Maintenance in the Cortical Proliferative Zone.Neuroscience · 2019Article
- Article
- Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration.Developmental biology · 2018Article
- Regulation of neural circuit formation by protocadherins.Cellular and molecular life sciences : CMLS · 2017Review
- Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.Chemical senses · 2017Review
- Regulation of Wnt signaling by protocadherins.Seminars in cell & developmental biology · 2017Review
- Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes.Journal of visualized experiments : JoVE · 2017Article
- Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine.BMC complementary and alternative medicine · 2015Article
- MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons.Human molecular genetics · 2014Article
- Activity-dependent genes in mouse olfactory sensory neurons.Chemical senses · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained elusive. Only a handful of genes have been identified whose expression is regulated by activity. Interestingly, all of these genes have been shown to play a role in OSN axon guidance, underscoring the importance of identifying other genes regulated by activity. Furthermore, studies suggest that more than one downstream mechanism regulates target gene expression. Thus, both the number of genes regulated by activity and how many total mechanisms control this expression are not well understood. Here we identify delta protocadherin 10 (pcdh10) as a gene regulated by activity. Delta protocadherins are members of the cadherin superfamily, and pcdh10 is known to be important for axon guidance during development. We show pcdh10 is expressed in the nasal epithelium and olfactory bulb in patterns consistent with providing guidance information to OSNs. We use naris occlusion, genetic manipulations, and pharmacological assays to show pcdh10 can be regulated by activity, consistent with activation via the cyclic nucleotide-gated channel. Transgenic analysis confirms a potential role for pcdh10 in OSN axon guidance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.