ArticleOman journal of ophthalmology2011
Association of vitamin D receptor gene start codon (Fok1) polymorphism with high myopia.
Article in Oman journal of ophthalmology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of exogenous calcitriol on myopia development and axial length in guinea pigs with form deprivation myopia.Scientific reports · 2024Article
- Vitamin D and myopia: a review.International ophthalmology · 2024Review
- Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility.BMC medical genomics · 2023Article
- Parallelism between hypovitaminosis D3 and recently detected myopia in children with amplified screen use in the COVID-19 era-A preliminary study.Indian journal of ophthalmology · 2023Article
- Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study.Journal of personalized medicine · 2022Article
- Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study.International journal of molecular sciences · 2022Article
- Association between serum vitamin D and refractive status in United States adolescents: A cross-sectional study.Frontiers in nutrition · 2022Article
- Myopia in India.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Genetic susceptibility to high myopia in Han Chinese population.Open life sciences · 2022Article
- Article
- Protective effects of increased outdoor time against myopia: a review.The Journal of international medical research · 2020Review
- Association between serum 25-hydroxyvitamin D levels and myopia in general Korean adults.Indian journal of ophthalmology · 2020Article
- Article
- Early Intervention and Nonpharmacological Therapy of Myopia in Young Adults.Journal of ophthalmology · 2018Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Serum 25-hydroxyvitamin D level is associated with myopia in the Korea national health and nutrition examination survey.Medicine · 2016Article
- Associations of vitamin D deficiency and vitamin D receptor (Cdx-2, Fok I, Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma.BMC ophthalmology · 2016Article
- Low serum vitamin D is associated with axial length and risk of myopia in young children.European journal of epidemiology · 2016Article
- Association of vitamin D receptor gene polymorphisms with polycystic ovary syndrome among Indian women.The Indian journal of medical research · 2015Article
- Vitamin D: Implications for ocular disease and therapeutic potential.Experimental eye research · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh myopia caused primarily due to abnormal emmetropization and excessive axial ocular elongation is associated with sight-threatening ocular pathology. Muscular dysfunction of ocular ciliary muscles due to altered intracellular calcium levels can result in defective mechanotransduction of the eye and retinal defocus. The vitamin D3 receptor (VDR; a intracellular hormone receptor) is known to mediate calcium homeostasis, influencing the development of myopia. MATERIALS AND
methodsIn the present study, a total of 206 high myopia, 98 low myopia and 250 control samples were analyzed for VDR gene Fok1 (exon 2 start codon) polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
resultsHigh myopia patients revealed decrease in the frequency of ff homozygotes (8.3%) as compared to control group (14.0%), with a corresponding increase in frequency of FF homozygotes (68.9% in high myopia vs. 62.8% in controls). The frequency of f allele carriers (Ff and ff) was increased in females of high myopia (35.6%) and low myopia cases (45.4%). Elevated frequency of f allele was found only in early age at onset cases of high myopia (0.227) and later age at onset (10-20 years) cases of low myopia (0.273) as well as in low myopia cases with parental consanguinity (0.458) (P 0.035; χ(2) = 6.692*).
conclusionThe results suggest that VDR gene might not be playing a direct role in the development of myopia, but might contribute indirectly to the risk conferred by mechanical stress factors or growth/development related factors through its role in calcium homeostasis and regulation of ciliary muscle function.
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