ArticleJournal of anaesthesiology, clinical pharmacology2011
Pregabalin in acute and chronic pain.
Article in Journal of anaesthesiology, clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01529190 (Effect of Preoperative Pregabalin on Pain Intensity and Interleukin-6 Levels in Living Donor Kidney), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Preoperative Pregabalin on Pain Intensity and Interleukin-6 Levels in Living Donor Kidney
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Interventions for treating pain and disability in adults with complex regional pain syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Comparison of the Efficacy and Safety of Pregabalin and Duloxetine in Taxane-Induced Sensory Neuropathy: A Randomized Controlled Trial.Clinical drug investigation · 2020Trial
- Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABABritish journal of anaesthesia · 2019Trial
- Sedative effects of oral pregabalin premedication on intravenous sedation using propofol target-controlled infusion.Journal of anesthesia · 2017Trial
- Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions.Bioactive materials · 2026Review
- Consensus on the Clinical Use of Pregabalin in Peripheral Neuropathic Pain.CNS neuroscience & therapeutics · 2026Review
- Postoperative pain management after ureteroscopy: focused approaches to reducing opiate dependence.Pain management · 2025Review
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- Article
- A critical review on the role of perioperative pregabalin in ureteroscopy for urolithiasis.Translational andrology and urology · 2024Article
- Neuropathic pain: Mechanisms and therapeutic strategies.Frontiers in cell and developmental biology · 2023Review
- Pregabalin Versus Duloxetine on Postoperative Analgesic Requirement Following Lower Extremity Trauma Surgeries: A randomised, Clinical Trial.Turkish journal of anaesthesiology and reanimation · 2022Article
- Fatalities associated with gabapentinoids in England (2004-2020).British journal of clinical pharmacology · 2022Article
- Symptom-based pharmacotherapy for neuropathic pain related to spinal disorders: results from a patient-based assessment.Scientific reports · 2022Article
- Challenges and opportunities in translational pain research - An opinion paper of the working group on translational pain research of the European pain federation (EFIC).European journal of pain (London, England) · 2021Article
- Comparison of the effect of oral pregabalin with intravenous ketamine on reducing acute pain after abdominal hysterectomy: A randomized double-blind clinical trial.Caspian journal of internal medicine · 2021Article
- Effectiveness of pregabalin as a secondary treatment for neuropathic pain from postherpetic neuralgia.Proceedings (Baylor University. Medical Center) · 2020Article
- Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study.Journal of orthopaedic surgery and research · 2020Article
- Outpatient narcotic consumption following total shoulder arthroplasty.JSES international · 2020Article
- Pregabalin as an analgesic option for patients undergoing thoracotomy: cost analysis of pregabalin versus epidural analgesia for post-thoracotomy pain relief.Journal of thoracic disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregabalin is a gamma-amino-butyric acid analog shown to be effective in several models of neuropathic pain, incisional injury, and inflammatory injury. In this review, the role of pregabalin in acute postoperative pain and in chronic pain syndromes has been discussed. Multimodal perioperative analgesia with the use of gabapentinoids has become common. Based on available evidence from randomized controlled trials and meta-analysis, the perioperative administration of pregabalin reduces opioid consumption and opioid-related adverse effects in the first 24 h following surgery. Postoperative pain intensity is however not consistently reduced by pregabalin. Adverse effects like visual disturbance, sedation, dizziness, and headache are associated with higher doses. The advantage of the perioperative use of pregabalin is so far limited to laparoscopic, gynecological, and daycare surgeries which are not very painful. The role of the perioperative administration of pregabalin in preventing chronic pain following surgery, its efficacy in more painful surgeries and surgeries done under regional anesthesia, and the optimal dosage and duration of perioperative pregabalin need to be studied. The efficacy of pregabalin in chronic pain conditions like painful diabetic neuropathy, postherpetic neuralgia, central neuropathic pain, and fibromyalgia has been demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.