ArticleEuropean journal of human genetics : EJHG2012
Imaging genetics of FOXP2 in dyslexia.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort.Scientific reports · 2016Pooled it
- Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.Autism research : official journal of the International Society for Autism Research · 2015Pooled it
- A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype.PloS one · 2013Trial
- Alterations in neural activation in the ventral frontoparietal network during complex magnocellular stimuli in developmental dyslexia associated with READ1 deletion.Behavioral and brain functions : BBF · 2024Article
- Role of forkhead box protein 2 (FOXP2) in oral-motor abilities of preterm infants: A brief literature review.Narra J · 2023Review
- Biolinguistics: A Scientometric Analysis of Research on (Children's) Molecular Genetics of Speech and Language (Disorders).Children (Basel, Switzerland) · 2022Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- FOXP transcription factors in vertebrate brain development, function, and disorders.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills.Human brain mapping · 2020Article
- Neuroimaging genetics studies of specific reading disability and developmental language disorder: A review.Language and linguistics compass · 2019Article
- Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.Translational psychiatry · 2019Article
- The interplay of socio-economic status represented by paternal educational level, white matter structure and reading.PloS one · 2019Article
- Article
- Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms.Translational psychiatry · 2017Review
- [Research advances in susceptible genes for developmental dyslexia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- Ultrasonic vocalization changes and FOXP2 expression after experimental stroke.Behavioural brain research · 2015Article
- Impact of pre-imputation SNP-filtering on genotype imputation results.BMC genetics · 2014Article
- Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.Human genetics · 2014Article
- Assessing the effects of common variation in the FOXP2 gene on human brain structure.Frontiers in human neuroscience · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslexia is a developmental disorder characterised by extensive difficulties in the acquisition of reading or spelling. Genetic influence is estimated at 50-70%. However, the link between genetic variants and phenotypic deficits is largely unknown. Our aim was to investigate a role of genetic variants of FOXP2, a prominent speech and language gene, in dyslexia using imaging genetics. This technique combines functional magnetic resonance imaging (fMRI) and genetics to investigate relevance of genetic variants on brain activation. To our knowledge, this represents the first usage of fMRI-based imaging genetics in dyslexia. In an initial case/control study (n = 245) for prioritisation of FOXP2 polymorphisms for later use in imaging genetics, nine SNPs were selected. A non-synonymously coding mutation involved in verbal dyspraxia was also investigated. SNP rs12533005 showed nominally significant association with dyslexia (genotype GG odds ratio recessive model = 2.1 (95% confidence interval 1.1-3.9), P = 0.016). A correlated SNP was associated with altered expression of FOXP2 in vivo in human hippocampal tissue. Therefore, influence of the rs12533005-G risk variant on brain activity was studied. fMRI revealed a significant main effect for the factor 'genetic risk' in a temporo-parietal area involved in phonological processing as well as a significant interaction effect between the factors 'disorder' and 'genetic risk' in activation of inferior frontal brain areas. Hence, our data may hint at a role of FOXP2 genetic variants in dyslexia-specific brain activation and demonstrate use of imaging genetics in dyslexia research.
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